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MABC266 Anti-Beclin-2 Antibody, clone 4H7.1

Anti-Beclin-2 Antibody, clone 4H7.1 is an antibody against Beclin-2 for use in western blotting & ICC.

Anti-Beclin-2 Antibody, clone 4H7.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: BECN1P1, BECN2 UniProt Number: E9KNW0
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MABC266
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, ICCMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABC266
DescriptionAnti-Beclin-2 Antibody, clone 4H7.1
Alternate Names
  • Beclin-2
Background InformationThe protein Beclin-2 is encoded by the gene BECN1P1/BECN2 and is involved in two important lysosomal degradation pathways in the brain and other tissues. Beclin-2 acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover. Beclin 2, which, like Beclin 1, functions in autophagy and interacts with class III PI3K complex components and Bcl-2. Beclin-2 is expressed in fetal and adult brain as well as other tissues. Beclin-2 is localized in the cytoplasm. Beclin-2 knockout mice have decreased embryonic viability, and heterozygous knockout mice have defective autophagy, increased levels of brain cannabinoid 1 receptor, elevated food intake, and obesity and insulin resistance. Thus because of its many cellular influences research into Beclin-2 regulation and function is ongoing.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-Beclin-2 Antibody, clone 4H7.1 is an antibody against Beclin-2 for use in western blotting & ICC.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application NotesImmunocytochemistry Analysis: A 1:250 dilution from a representative lot detected Beclin-2 in A431 cells without and with serum starvation (Note: Increased punctate staining is associated with increased levels of autophagy under serum starved conditions).
Biological Information
ImmunogenRecombinant protein corresponding to the Coiled coil domain of human Beclin-2.
EpitopeCoiled coil domain
Clone4H7.1
Concentration0.5 mg/mL
HostMouse
IsotypeIgMκ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Gene Symbol
  • BECN1P1
  • BECN2
Purification MethodPurified by Ion-Exchange Chromatography
UniProt Number
Molecular Weight~48 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in human fetal brain tissue lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected Beclin-2 in 10 µg of human fetal brain tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABC266 04053252975585