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AB2232 Anti-Atrial Natriuretic Polypetide Antibody, alpha

This Anti-Atrial Natriuretic Polypetide Antibody, alpha is validated for use in WB for the detection of Atrial Natriuretic Polypetide.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurotransmitters & Receptors Gene Symbol: ANF , ANP, CDD-ANF, OTTHUMP00000002504, OTTHUMP00000044485, PND , Prepronatriodilatin, pronatriodilatin UniProt Number: P01160
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AB2232
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, RWBRbPurifiedPolyclonal Antibody
Description
Catalogue NumberAB2232
DescriptionAnti-Atrial Natriuretic Polypetide Antibody, alpha
Alternate Names
  • Atrial natriuretic peptide
  • natriuretic peptide precursor A
  • natriuretic peptide precursor A variant 2
Background InformationAtrial natriuretic polypeptide, alpha (ANP), atrial natriuretic factor (ANF), or atriopeptin, is a protein (polypeptide) hormone secreted by heart muscle cells. It is involved in the homeostatic control of body water, sodium, potassium and fat (adiposity). It is released by muscle cells in the upper chambers (atria) of the heart (atrial myocytes), in response to high blood pressure. ANP acts to reduce the water, sodium and adipose loads on the circulatory system, thereby reducing blood pressure. ANP binds to a specific set of receptors - ANP receptors. Receptor-agonist binding causes a reduction in blood volume and therefore a reduction in cardiac output and systemic blood pressure. Lipolysis is increased and renal sodium reabsorption is decreased. The overall effect of ANP on the body is to counter increases in blood pressure and volume caused by the renin-angiotensin system (1).
References
Product Information
FormatPurified
Control
  • Rat Heart
PresentationPurified in 0.1M Tris-Glycine (pH7.4) 15mM NaCl with 0.05% NaN3
Quality LevelMQ100
Applications
ApplicationThis Anti-Atrial Natriuretic Polypetide Antibody, alpha is validated for use in WB for the detection of Atrial Natriuretic Polypetide.
Key Applications
  • Western Blotting
Application NotesNon-Lot Specific Tested Application 1:
Immunohistochemistry:
1:50-1:500 on paraffin embedded tissue.

Optimum dilutions need to be determined by the end user.
Biological Information
ImmunogenSynthetic Linear Peptide
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityCat. # AB2232 recognizes ANP, alpha
Species Reactivity
  • Human
  • Mouse
  • Rat
Species Reactivity NoteRat, Human and Mouse. May react with dog, cat and cow based on sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • ANF
  • ANP
  • CDD-ANF
  • OTTHUMP00000002504
  • OTTHUMP00000044485
  • PND
  • Prepronatriodilatin
  • pronatriodilatin
Purification MethodPurified
UniProt Number
UniProt SummaryFUNCTION: A potent vasoactive substance which is thought to play a key role in cardiovascular homeostasis. Has a cGMP-stimulating activity.
SUBUNIT: Interacts with NPR3.
LOCATION: Secreted.
POLYMORPHISM: There are two different prepronatriodilatin alleles. One codes for 2 Arg residues at the C-terminus that are cleaved to form the mature peptide, while the other ends in a termination codon immediately after the last codon of the mature peptide.
SIMILARITY: Belongs to the natriuretic peptide family.
Molecular Weight~17 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by western blot
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Handling Recommendations: Prior to removing the cap, gently centrifuge the vial and gently mix the solution.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
AB2232 04053252621215

Documentation

Anti-Atrial Natriuretic Polypetide Antibody, alpha MSDS

Title

Safety Data Sheet (SDS) 

Anti-Atrial Natriuretic Polypetide Antibody, alpha Certificates of Analysis

TitleLot Number
Anti-Atrial Natriuretic Polypeptide, -2796324 2796324
Anti-Atrial Natriuretic Polypeptide, alpha - 2117252 2117252
Anti-Atrial Natriuretic Polypeptide, alpha - 2161143 2161143
Anti-Atrial Natriuretic Polypeptide, alpha - 2424500 2424500
Anti-Atrial Natriuretic Polypeptide, alpha - 2455728 2455728
Anti-Atrial Natriuretic Polypeptide, alpha - 2110005 2110005
Anti-Atrial Natriuretic Polypeptide, alpha - 2343589 2343589
Anti-Atrial Natriuretic Polypeptide, alpha - 3856689 3856689
Anti-Atrial Natriuretic Polypeptide, alpha - NG1809713 NG1809713
Anti-Atrial Natriuretic Polypeptide, alpha - NG1917782 NG1917782
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References

Reference overviewPub Med ID
Atrial natriuretic factor: a hormone produced by the heart.
de Bold, A J
Science, 230: 767-70 (1985)  1985

2932797 2932797