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MAB3773 Anti-Annexin I Antibody, clone 6E4/3

Anti-Annexin I Antibody, clone 6E4/3 detects level of Annexin I & has been published & validated for use in ELISA, IF & WB.

Anti-Annexin I Antibody, clone 6E4/3 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: ANXA1, LPC1, Annexin-1, Chromobindin-9, ANX1, p35 UniProt Number: P04083
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MAB3773
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HELISA, IF, WBMPurifiedMonoclonal Antibody
Description
Catalogue NumberMAB3773
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Annexin I Antibody, clone 6E4/3
Alternate Names
  • Lipocortin I
  • Calpactin II
  • Chromobindin 9
  • Phospholipase A2 Inhibitory Protein
Background InformationAnnexin I belongs to a family of Ca2+ dependent phospholipid binding proteins. It has been implicated in the regulation of phagocytosis, cell signaling and cell proliferation.
References
Product Information
FormatPurified
PresentationPurified immunoglobulin. Liquid in 0.02M phosphate buffer, 0.25M NaCl, pH 7.6, with 0.1% sodium azide
Quality LevelMQ100
Applications
ApplicationAnti-Annexin I Antibody, clone 6E4/3 detects level of Annexin I & has been published & validated for use in ELISA, IF & WB.
Key Applications
  • ELISA
  • Immunofluorescence
  • Western Blotting
Application NotesWestern blot

Immunofluorescence

ELISA

Optimal working dilutions must be determined by end user.
Biological Information
ImmunogenWhole native annexin proteins contained in a mixture of membrane proteins from human bone tissue
Clone6E4/3
HostMouse
SpecificityRecognizes human Annexin I
IsotypeIgG1
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryAnnexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity.
Gene Symbol
  • ANXA1
  • LPC1
  • Annexin-1
  • Chromobindin-9
  • ANX1
  • p35
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P04083 # Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity.
SIZE: 346 amino acids; 38714 Da
SUBUNIT: Homodimer in placenta (20%); linked by transglutamylation.
SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Cell projection, cilium (By similarity). Basolateral cell membrane (By similarity). Note=Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium (By similarity). Found in the cytoplasm of type II pneumocytes and alveolar macrophages (By similarity).
DOMAIN: SwissProt: P04083 A pair of annexin repeats may form one binding site for calcium and phospholipid.
PTM: Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in loss of the inhibitory activity.SIMILARITY: Belongs to the annexin family. & Contains 4 annexin repeats.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 12 months from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MAB3773 04053252663307

Documentation

Anti-Annexin I Antibody, clone 6E4/3 MSDS

Title

Safety Data Sheet (SDS) 

Anti-Annexin I Antibody, clone 6E4/3 Certificates of Analysis

TitleLot Number
MOUSE ANTI-ANNEXIN I MONOCLONAL ANTIBODY 3315987
MOUSE ANTI-ANNEXIN I MONOCLONAL ANTIBODY - 2136613 2136613
MOUSE ANTI-ANNEXIN I MONOCLONAL ANTIBODY - 2141812 2141812
MOUSE ANTI-ANNEXIN I MONOCLONAL ANTIBODY - 2143459 2143459
MOUSE ANTI-ANNEXIN I MONOCLONAL ANTIBODY - 2148887 2148887
MOUSE ANTI-ANNEXIN I MONOCLONAL ANTIBODY - 2370677 2370677
MOUSE ANTI-ANNEXIN I -2832231 2832231
MOUSE ANTI-ANNEXIN I MONOCLONAL ANTIBODY 2989479