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129876 Amiloride, Hydrochloride - CAS 2016-88-8 - Calbiochem

An inhibitor of angiogenesis.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Acid-Sensing Ion Channel Modulator I, ASIC Channel Modulator I

Primary Target: capillary morphogenesis
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
2016-88-8C₆H₈ClN₇O • HCl

Products

Catalogue NumberPackaging Qty/Pack
129876-100MGCN 鋁桶 100 mg
Description
OverviewAn inhibitor of angiogenesis. Inhibits capillary morphogenesis completely and reversibly at approximately 130 µM. At low concentrations, acts as a potent and specific inhibitor of transmembrane Na+ entry and Na+,K+-ATPase. Also acts as an inhibitor of urokinase-type plasminogen activator (uPA). Blocks smooth muscle responses to contractile stimuli and palytoxin-induced conductance in skeletal muscle. Reduces electrical potential across tubular epithelium. At higher concentrations, blocks the Na+/H+ exchange pathway.
Catalogue Number129876
Brand Family Calbiochem®
SynonymsAcid-Sensing Ion Channel Modulator I, ASIC Channel Modulator I
References
ReferencesKnoll, A., et al. 1999. Microvasc. Res. 58, 1.
Swiercz, R., et al. 1999. Oncol. Rep. 6, 523.
Moran, A., et al. 1995. Am. J. Physiol. 268, C350.
Alliegro, M.C., et al. 1993. J. Exp. Zool. 267, 245.
Sugiyama, S., et al. 1988. J. Biol. Chem. 263, 8215.
Yoshida, K., et al. 1988. Biochem. Biophys. Res. Commun. 154, 101.
Sariban-Sotorabay, S., and Benos, D.J. 1986. Am. J. Physiol. 250, C175.
Product Information
CAS number2016-88-8
ATP CompetitiveN
FormOff-white to yellow solid
Hill FormulaC₆H₈ClN₇O • HCl
Chemical formulaC₆H₈ClN₇O • HCl
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetcapillary morphogenesis
Primary Target IC<sub>50</sub>130 µM inhibiting capillary morphogenesis completely and reversibly
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSUQ2275500
Safety Information
R PhraseR: 25

Toxic if swallowed.
S PhraseS: 45-36

In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +15°C to +30°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
129876-100MGCN 04055977222289

Documentation

Amiloride, Hydrochloride - CAS 2016-88-8 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Amiloride, Hydrochloride - CAS 2016-88-8 - Calbiochem Certificates of Analysis

TitleLot Number
129876

References

Reference overview
Knoll, A., et al. 1999. Microvasc. Res. 58, 1.
Swiercz, R., et al. 1999. Oncol. Rep. 6, 523.
Moran, A., et al. 1995. Am. J. Physiol. 268, C350.
Alliegro, M.C., et al. 1993. J. Exp. Zool. 267, 245.
Sugiyama, S., et al. 1988. J. Biol. Chem. 263, 8215.
Yoshida, K., et al. 1988. Biochem. Biophys. Res. Commun. 154, 101.
Sariban-Sotorabay, S., and Benos, D.J. 1986. Am. J. Physiol. 250, C175.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-April-2009 JSW
SynonymsAcid-Sensing Ion Channel Modulator I, ASIC Channel Modulator I
DescriptionAn inhibitor of angiogenesis. At low concentrations, acts as a potent and specific inhibitor of transmembrane Na+ entry and Na+/H+ ATPase. Inhibits smooth muscle responses to contractile stimuli. Blocks palytoxin-induced conductance in skeletal muscle. Reduces the electrical potential across tubular epithelium. At higher concentrations, blocks the Na+/H+ exchange pathway.
FormOff-white to yellow solid
CAS number2016-88-8
RTECSUQ2275500
Chemical formulaC₆H₈ClN₇O • HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (5 mg/ml) or H₂O (2.5 mg/ml)
Storage Protect from light
+15°C to +30°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 6 months at -20°C.
Toxicity Toxic
Merck USA index14, 406
ReferencesKnoll, A., et al. 1999. Microvasc. Res. 58, 1.
Swiercz, R., et al. 1999. Oncol. Rep. 6, 523.
Moran, A., et al. 1995. Am. J. Physiol. 268, C350.
Alliegro, M.C., et al. 1993. J. Exp. Zool. 267, 245.
Sugiyama, S., et al. 1988. J. Biol. Chem. 263, 8215.
Yoshida, K., et al. 1988. Biochem. Biophys. Res. Commun. 154, 101.
Sariban-Sotorabay, S., and Benos, D.J. 1986. Am. J. Physiol. 250, C175.