178501 Sigma-AldrichAPT1 Inhibitor, palmostatin B - Calbiochem
APT1 Inhibitor, Palmostatin B is a cell-permeable inhibitor of acyl protein thioesterase 1 (IC50 = 0.67 µM) that specifically block Ras depalmitoylation, without affecting Ras acylation.
More>> APT1 Inhibitor, Palmostatin B is a cell-permeable inhibitor of acyl protein thioesterase 1 (IC50 = 0.67 µM) that specifically block Ras depalmitoylation, without affecting Ras acylation. Less<<Synonyms: APT1 Inhibitor
Recommended Products
-
802458 Sigma-Aldrich 4-氯苯乙烯 -
07-529 Sigma-Aldrich Anti-KIF21A Antibody -
MAB3584 Sigma-Aldrich Anti-Heterochromatin Protein-1 α Antibody, clone 2HP-1H5 -
1500820001 Supelco 25-4mm專用套管連接頭 -
GM50/4A01-6440 Millipore GMP5000 Drive unit 7,5:1 Ext 0, FDA Gree -
TMTP02500 Millipore Isopore Membrane Filter -
N17-25R Millipore NA25 Support gasket for PTFE diaphragm -
ZTC04S960 Millipore ZipTip with 0.6 µL C4 resin -
1074309010 SAFC 脯氨酸 -
NU150/39-211 Millipore NovAseptic Valve, Valve Body, Divert Valve
Overview
Key Spec Table
Empirical Formula |
---|
C₂₃H₃₆O₄ |
Products
Catalogue Number | Packaging | Qty/Pack | |
---|---|---|---|
178501-5MGCN | 玻璃瓶 | 5 mg |
Description | |
---|---|
Overview | A cell-permeable, beta-lactone acyl protein thioesterase 1 (APT1) inhibitor (IC50 = 0.67 µM, in an enzymatic assay) that is shown to specifically block Ras depalmitoylation, without affecting Ras acylation, in MDCK cells, both in vitro and in vivo. It induces a marked redistribution of NRas to endomembranes (1 µM) without notable cytotoxicity, and is shown to elicit a loss of the precise steady-state localization of palmitoylated Ras proteins in the same cell line. At 50 µM, this inhibitor displays a partial phenotypic reversion in oncogenic HRasG12V-transformed fibroblasts. Furthermore, it demonstrates selectivity for APT1 over phospholipase A1, A2, Cβ and D. It's inhibitory effect is demonstrated to be consistent with that of APT1 downregulation by siRNA. Also available as a 50 mM solution in DMSO (Cat. No. 508738). |
Catalogue Number | 178501 |
Brand Family | Calbiochem® |
Synonyms | APT1 Inhibitor |
References | |
---|---|
References | Dekker, F. and Hedberg, C. 2011. Bioorg. Med. Chem. Lett. 19, 1376. Dekker, F., et al. 2010. Nat. Chem. Biol. 6, 449. |
Product Information | |
---|---|
Form | Off-white solid |
Hill Formula | C₂₃H₃₆O₄ |
Chemical formula | C₂₃H₃₆O₄ |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
---|---|
Purity | ≥95% by HPLC |
Packaging Information | |
---|---|
Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
---|---|
Catalogue Number | GTIN |
178501-5MGCN | 04055977204834 |