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345868 [6]-Gingerol, Zingiber officinale - CAS 23513-14-6 - Calbiochem

An antitumor, apoptosis-inducing compound of the ginger family that blocks EGF-induced cell transformation by inhibiting the activation of Activator Protein-1 (AP-1).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-(4ʹ-Hydroxy-3ʹ-methoxyphenyl)-5-hydroxy-3-decanone

Primary Target: Activator Protein-1 (AP-1)
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
23513-14-6C₁₇H₂₆O₄

Products

Catalogue NumberPackaging Qty/Pack
345868-5MGCN 塑膠安瓿;塑膠針藥瓶 5 mg
Description
OverviewAn antitumor, apoptosis-inducing compound of the ginger family that blocks EGF-induced cell transformation by inhibiting the activation of Activator Protein-1 (AP-1). Also increases the Ca2+-ATPase activity in cardiac sarcoplasmic reticulum (EC50 = 4 µM) and increases Ca2+ uptake.
Catalogue Number345868
Brand Family Calbiochem®
Synonyms1-(4ʹ-Hydroxy-3ʹ-methoxyphenyl)-5-hydroxy-3-decanone
References
ReferencesBode, A.M., et al. 2001. Cancer Res. 61, 850.
Antipenko, A.Y., et al. 1999. J. Pharmacol. Exp. Ther. 290, 227.
Park, K.K.,et al. 1998. Cancer Lett. 129, 139.
Kobayashi, M., et al. 1987. Biochim. Biophys. Acta 903, 96.
Product Information
CAS number23513-14-6
ATP CompetitiveN
FormPale yellow oil
Hill FormulaC₁₇H₂₆O₄
Chemical formulaC₁₇H₂₆O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetActivator Protein-1 (AP-1)
Primary Target IC<sub>50</sub>EC50 = 4 µM increasing the Ca2+-ATPase activity in cardiac sarcoplasmic reticulum
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSHE0757000
Safety Information
R PhraseR: 20/21/22-36/37/38

Harmful by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
345868-5MGCN 04055977214437

Documentation

[6]-Gingerol, Zingiber officinale - CAS 23513-14-6 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

[6]-Gingerol, Zingiber officinale - CAS 23513-14-6 - Calbiochem Certificates of Analysis

TitleLot Number
345868

References

Reference overview
Bode, A.M., et al. 2001. Cancer Res. 61, 850.
Antipenko, A.Y., et al. 1999. J. Pharmacol. Exp. Ther. 290, 227.
Park, K.K.,et al. 1998. Cancer Lett. 129, 139.
Kobayashi, M., et al. 1987. Biochim. Biophys. Acta 903, 96.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-June-2008 RFH
Synonyms1-(4ʹ-Hydroxy-3ʹ-methoxyphenyl)-5-hydroxy-3-decanone
DescriptionPhytochemical compound isolated from the extract of rhizome of ginger. Along with other related compounds found in ginger extracts inhibits prostaglandin and leukotriene biosynthesis through the suppression of 5-lipoxygenase and prostaglandin synthetase. Also exhibits anti-tumor and apoptosis-inducing effects. Blocks EGF-induced cell transformation by inhibiting the activation of Activator protein-1 (AP-1). Shown to inhibit the EGF-induced, sequence-specific DNA-binding of AP-1. Does not effect EGF-induced phosphorylation of ERK or p38 kinases. Also increases the Ca2+-ATPase activity of the sarcoplasmic reticulum (EC50 = 4 µM).
FormPale yellow oil
Intert gas (Yes/No) Packaged under inert gas
CAS number23513-14-6
RTECSHE0757000
Chemical formulaC₁₇H₂₆O₄
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months -20°C.
Toxicity Harmful
ReferencesBode, A.M., et al. 2001. Cancer Res. 61, 850.
Antipenko, A.Y., et al. 1999. J. Pharmacol. Exp. Ther. 290, 227.
Park, K.K.,et al. 1998. Cancer Lett. 129, 139.
Kobayashi, M., et al. 1987. Biochim. Biophys. Acta 903, 96.