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100065 2-APB - CAS 524-95-8 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
524-95-8C₁₄H₁₆BNO

Products

Catalogue NumberPackaging Qty/Pack
100065-100MGCN 玻璃瓶 100 mg
Description
OverviewA cell-permeable modulator of Ins(1,4,5)P3-induced Ca2+ release. Inhibits Ins(1,4,5)P3-induced Ca2+ release from rat cerebellar microsomal preparations (IC50 = 42 µM) without affecting [3H]-Ins(1,4,5)P3 binding to its receptor. Does not affect Ca2+ release from the ryanodine-sensitive Ca2+ store in rat leg skeletal muscle and heart. Inhibits spontaneous as well as the phasic contractions induced by uterotonic agents. Also reported to inhibit angiotensin II-induced contractions in aortic muscles.
Catalogue Number100065
Brand Family Calbiochem®
Synonyms2-Aminoethoxydiphenylborate, (2-Aminoethoxy)diphenylborane
References
ReferencesBrooke, R. T., et al. 2004. Lab. Invest. 84, 29.
Gregory, R.B., et al. 2001. Biochem. J. 354, 285.
Ma, H.T., et al. 2001. J. Biol. Chem. 276, 18888.
Ascher-Landsberg, S., et al. 1999. Biochem. Biophys. Res. Commun. 264, 979.
Maruyama, T., et al. 1997. J. Biochem. 122, 498.
Product Information
CAS number524-95-8
ATP CompetitiveN
FormWhite crystalline solid
Hill FormulaC₁₄H₁₆BNO
Chemical formulaC₁₄H₁₆BNO
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetIns(1,4,5)P3-induced Ca2+ release
Primary Target IC<sub>50</sub>42 µM against Ins(1,4,5)P3-induced Ca2+ release from rat cerebellar microsomal preparations
Purity≥97% by titration
Physicochemical Information
Cell permeableY
Safety Information according to GHS
RTECSED6150000
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
100065-100MGCN 07790788056766