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565749 β-Secretase Inhibitor II - CAS 263563-09-3 - Calbiochem

The β-Secretase Inhibitor II, also referenced under CAS 263563-09-3, controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Z-VLL-CHO, N-Benzyloxycarbonyl-Val-Leu-leucinal

Primary Target: β-secretase
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565749
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
263563-09-3C₂₅H₃₉N₃O₅

Products

Catalogue NumberPackaging Qty/Pack
565749-1MGCN 塑膠安瓿;塑膠針藥瓶 1 mg
565749-5MGCN 塑膠安瓿;塑膠針藥瓶 5 mg
Description
OverviewA potent, cell-permeable, and reversible inhibitor of β-secretase. Corresponds to the β-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Aβtotal (IC50 = 700 nM) and Aβ1-42 (IC50 = 2.5 µM) in Chinese hamster ovary (CHO) cells stable transfected with wild-type APP751.
Catalogue Number565749
Brand Family Calbiochem®
SynonymsZ-VLL-CHO, N-Benzyloxycarbonyl-Val-Leu-leucinal
References
ReferencesAbbenante, G., et al. 2000. Biochem. Biophys. Res. Commun. 268, 133.
Product Information
CAS number263563-09-3
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₅H₃₉N₃O₅
Chemical formulaC₂₅H₃₉N₃O₅
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetβ-secretase
Primary Target IC<sub>50</sub>700 nM and 2.5 µM against Aβtotal and Aβ1-42, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceZ-Val-Leu-Leu-CHO
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
565749-1MGCN 04055977267655
565749-5MGCN 04055977267662

Documentation

β-Secretase Inhibitor II - CAS 263563-09-3 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

β-Secretase Inhibitor II - CAS 263563-09-3 - Calbiochem Certificates of Analysis

TitleLot Number
565749

References

Reference overview
Abbenante, G., et al. 2000. Biochem. Biophys. Res. Commun. 268, 133.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-April-2011 RFH
SynonymsZ-VLL-CHO, N-Benzyloxycarbonyl-Val-Leu-leucinal
DescriptionA potent, cell-permeable, and reversible inhibitor of β-secretase that corresponds to the β-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Aβtotal (IC50 = 700 nM) and Aβ1-42 (IC50 = 2.5 µM) in Chinese hamster ovary (CHO) cells stably transfected with wild-type APP751.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number263563-09-3
Chemical formulaC₂₅H₃₉N₃O₅
Peptide SequenceZ-Val-Leu-Leu-CHO
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesAbbenante, G., et al. 2000. Biochem. Biophys. Res. Commun. 268, 133.