Chromolith® Prep |
Chromolith® Prep monolithic columns are ultra-pure silica stationary phases specially designed for high efficiency, high speed preparative chromatography. Based on the new sol-gel technology, the columns consist of a unique bimodal pore structure with macro- and mesopores.
Having an average diameter of 12 nm, the mesopores form the fine porous structure of the column interior, creating a very large surface area on which adsorption of target compounds can occur. The large macropores, with a diameter of 3 μm, form a dense network, which reduces resistance, thus allowing high flow rates.
The excellent accessibility of the mesopores (total porosity > 80%) and short diffusion length inside the pores ensure fast adsorption and desorption kinetics. As a result, Chromolith® Prep monolithic columns dramatically reduce separation times while increasing productivity.
Features and Benefits
- Low pressure drop at a higher flow rate
- High porosity assures fast adsorption and desorption kinetics
- Shorter separation times and less solvent consumption compared to particulate sorbents
- Higher productivity and greater efficiency compared to particulate sorbents
Chromolith® Prep Si and RP-18e: Typical Technical Data
| Macropore size | 3 μm |
|---|---|
| Mesopore size | 12 nm (120 Å) |
| Specific pore volume | 1 mL/g |
| Specific surface area | 350 m2/g |
| Packing density | 0.2 g/mL |
| Total porosity | 0.8 |
| Surface pH | neutral |
| Dimension | 100-25 mm |
| Maximum operating pressure | 100 bar (1450 psi) |
Chromolith® Prep Product Range
The ready-to-use columns are cladded with a polymeric material (PEEK), and can be connected directly to any HPLC system.
| Catalog Number | Catalog Name | |
|---|---|---|
| 125252 | Chromolith® Prep RP-18 endcapped 100-25 column (Chromolith® Prep RP-18 endcapped 100-25 column) |
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| 125251 | Chromolith® Prep Si 100-25 column (Chromolith® Prep Si 100-25 column) |
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| 152035 | Chromolith® SemiPrep Si 10-10 guard cartridges (3 pieces) (Chromolith® SemiPrep Si 10-10 guard cartridges (3 pieces)) |
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| 152036 | Chromolith® SemiPrep RP-18 endcapped 10-10 guard cartridges (3 pieces) (Chromolith® SemiPrep RP-18 endcapped 10-10 guard cartridges (3 pieces)) |
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| 152037 | Chromolith® SemiPrep 10-10 guard cartridge holder (Chromolith® SemiPrep 10-10 guard cartridge holder) |
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| 152015 | Chromolith® SemiPrep Si 100-10 column (Chromolith® SemiPrep Si 100-10 column) |
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| 152016 | Chromolith® SemiPrep RP-18 endcapped 100-10 column (Chromolith® SemiPrep RP-18 endcapped 100-10 column) |
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