EX-CELL^® Advanced HD Perfusion Medium

The next generation of perfusion processes requires a completely new type of medium to facilitate high productivity at low perfusion rates. It has been specifically designed to meet such manufacturing requirements:

• High density cell culture medium
• Facilitates high productivity at low perfusion rates
• Increases production yield

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Phospho-Tyrosine Disodium Salt EMPROVE^® EXPERT

Phospho-Tyrosine Disodium Salt Emprove^® EXPERT is an in-house manufactured amino acid derivative with specific properties enabling the intensification of cell culture processes. Together with the companion product Sulfo-Cysteine sodium salt, the modified amino acid Phospho-Tyrosine disodium salt can be used as replacement for tyrosine to generate highly concentrated, neutral pH feeds.

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L-Cysteine S-Sulfate Sodium Sesquihydrate EMPROVE^® EXPERT

This in-house manufactured modified amino acid S-Sulfocysteine sodium salt can be used as replacement for cysteine to generate highly concentrated, neutral pH feeds. It eliminates the need for alkaline feeds, which are normally applied to ensure solubility and stability of the unmodified amino acid cysteine.

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pDADMAC Flocculation Polymer

The current evolution to high cell density and high product titer cell cultures is placing a larger burden on traditional downstream clarification and purification operations Polycationic polymer modified poly (diallyldimethyl-ammonium chloride) [pDADMAC] is a very effective flocculation polymer that can be used as a pre-treatment solution when used in combination with our Clarisolve^® depth filters.

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Mobius^® Single-use Bioreactors

Mobius^® Single-Use Bioreactors are a scalable portfolio of stirred tank bioreactors that provide flexibility by configuring software, hardware, and single-use assemblies for use in suspension and adherent cell culture applications. The Mobius^® Bioreactor family includes the bench scale (3 L), pilot-scale (50 L and 200 L), and clinical scale (1000 L and 2000 L) bioreactors that enable cell culturing capabilities for early process development through clinical batch production.

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Clarisolve^® Depth Filter

The Clarisolve^® depth filter disposes of a gradient density structure specifically designed to the particle size distributions of pretreated feed streams.

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Millistak+^® HC Pro Depth Filter

Millistak+^® HC Pro (High Capacity Synthetic Media) is a synthetic depth filter providing a cleaner and more consistent depth filtration media over current diatomaceous earth (DE) and cellulose (CE) based filter media.

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