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Parathyroid

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Parathyroid hormone signaling via Gαs is selectively inhibited by an NH(2)-terminally truncated Gαs: implications for pseudohypoparathyroidism.
Pseudohypoparathyroid patients have resistance predominantly to parathyroid hormone (PTH), and here we have examined the ability of an alternative Gαs-related protein to inhibit Gαs activity in a hormone-selective manner. We tested whether the GNAS exon A/B-derived NH(2)-terminally truncated (Tr) αs protein alters stimulation of...
Document Type:

Reference

Product Catalog Number:

06-237
Product Catalog Name:

Anti-Gsα Antibody (Anti-Gsα Antibody)
Involvement of parathyroid hormone-related protein in experimental cachexia induced by a human lung cancer-derived cell line established from a bone metastasis specimen.
Cachexia often causes deterioration in the quality of life in cancer patients; however, its mechanism remains poorly understood. Cachexia has often been observed in experimental animals with bone metastases, and parathyroid hormone-related protein (PTHrP) plays an important role in the formation of such metastases. We therefore...
Document Type:

Reference

Product Catalog Number:

MABN793
Product Catalog Name:

Anti-PTHrP (1-34) Antibody, clone 23-57-137-1 (Anti-PTHrP (1-34) Antibody, clone 23-57-137-1)
Parathyroid Hormone-Like Hormone is a Poor Prognosis Marker of Head and Neck Cancer and Promotes Cell Growth via RUNX2 Regulation.
Parathyroid Hormone-Like Hormone (PTHLH) is an autocrine/paracrine ligand that is up-regulated in head and neck squamous cell carcinoma (HNSCC). However, the cellular function and regulatory mechanism in HNSCC remains obscure. We investigated the clinical significance of PTHLH in HNSCC patients, and verified the role of RUNX2/PT...
Document Type:

Reference

Product Catalog Number:

17-375
Product Catalog Name:

EZ-Zyme™ Chromatin Prep Kit (EZ-Zyme™ Chromatin Prep Kit)
Parathyroid hormone-(1-34) enhances aggrecan synthesis via an insulin-like growth factor-I pathway
Document Type:

Reference

Product Catalog Number:

Multiple
Product Catalog Name:

Multiple
Parathyroid hormone-related protein inhibits DKK1 expression through c-Jun-mediated inhibition of β-catenin activation of the DKK1 promoter in prostate cancer.
Prostate cancer (PCa)bone metastases are unique in that majority of them induce excessive mineralized bone matrix, through undefined mechanisms, as opposed to most other cancers that induce bone resorption. Parathyroid hormone-related protein (PTHrP) is produced by PCa cells and intermittent PTHrP exposure has bone anabolic effe...
Document Type:

Reference

Product Catalog Number:

Multiple
Product Catalog Name:

Multiple
Parathyroid hormone receptor directly interacts with dishevelled to regulate beta-Catenin signaling and osteoclastogenesis.
Bone growth and remodeling depend upon the opposing rates of bone formation and resorption. These functions are regulated by intrinsic seven transmembrane-spanning receptors, the parathyroid hormone receptor (PTH1R) and frizzled (FZD), through their respective ligands, parathyroid hormone (PTH) and Wnt. FZD activation of canonic...
Document Type:

Reference

Product Catalog Number:

Multiple
Product Catalog Name:

Multiple
Parathyroid hormone induction of cyclooxygenase-2 in murine osteoblasts: role of the calcium-calcineurin-NFAT pathway.
Murine MC3T3-E1 and MC-4 cells were stably transfected with -371/+70 bp of the murine cyclooxygenase-2 (COX-2) promoter fused to a luciferase reporter (Pluc371) or with Pluc371 carrying site-directed mutations. Mutations were made in (1) the cAMP response element (CRE) at -57/-52 bp, (2) the activating protein-1 (AP-1)-binding s...
Document Type:

Reference

Product Catalog Number:

17-371
Product Catalog Name:

EZ-ChIP™ (EZ-ChIP™)
Parathyroid hormone exerts disparate effects on osteoblast differentiation depending on exposure time in rat osteoblastic cells
Document Type:

Reference

Product Catalog Number:

05-172
Product Catalog Name:

Anti-IGF-I Antibody, clone Sm1.2 (Anti-IGF-I Antibody, clone Sm1.2)
Over-expression of parathyroid hormone Type 1 receptor confers an aggressive phenotype in osteosarcoma.
Osteosarcoma is the most common primary bone malignancy in children and is associated with rapid bone growth. Parathyroid hormone-related peptide (PTHrP) signaling via parathyroid hormone Type 1 receptor (PTHR1) is important for skeletal development and is involved in bone metastases in other tumors. The aim of this study was to...
Document Type:

Reference

Product Catalog Number:

06-870
Osteoblastic expansion induced by parathyroid hormone receptor signaling in murine osteocytes is not sufficient to increase hematopoietic stem cells.
Microenvironmental expansion of hematopoietic stem cells (HSCs) is induced by treatment with parathyroid hormone (PTH) or activation of the PTH receptor (PTH1R) in osteoblastic cells; however, the osteoblastic subset mediating this action of PTH is unknown. Osteocytes are terminally differentiated osteoblasts embedded in mineral...
Document Type:

Reference

Product Catalog Number:

AB5922