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506163 p38 MAP Kinase Inhibitor VIII - CAS 321351-00-2 - Calbiochem

The p38 MAP Kinase Inhibitor VIII, also referenced under CAS 321351-00-2, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (4-((2-Amino-4-bromophenyl)amino)-2-chlorophenyl)-(2-methylphenyl)methanone

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506163
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
321351-00-2C₂₀H₁₆BrClN₂O

Products

Catalogue NumberPackaging Qty/Pack
506163-5MGCN Plastic ampoule 5 mg
Description
OverviewA cell-permeable aminobenzophenone compound that acts as a potent, ATP-binding pocket-targeting inhibitor against p38α and p38β2 (82% and 93% inhibition with 1 µM inhibitor, respectively; IC50 of p38α inhibition = 40 nM) with little activity against a panel of 57 other kinases, including p38γ, p38δ, Erk1/2, and JNK1. Shown to inhibit LPS-induced cytokine productions in human PBMC's in vitro and exhibit in vivo efficacy in both acute and chronic murine models of skin inflammation.
Catalogue Number506163
Brand Family Calbiochem®
Synonyms(4-((2-Amino-4-bromophenyl)amino)-2-chlorophenyl)-(2-methylphenyl)methanone
References
ReferencesOttosen, E.R., et al. 2003. J. Med. Chem. 46, 5651.
Product Information
CAS number321351-00-2
FormYellow solid
Hill FormulaC₂₀H₁₆BrClN₂O
Chemical formulaC₂₀H₁₆BrClN₂O
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
S PhraseS: 22-24/25-36/37/39-45

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
506163-5MGCN 04055977272307

Documentation

p38 MAP Kinase Inhibitor VIII - CAS 321351-00-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

p38 MAP Kinase Inhibitor VIII - CAS 321351-00-2 - Calbiochem Certificates of Analysis

TitleLot Number
506163

References

Reference overview
Ottosen, E.R., et al. 2003. J. Med. Chem. 46, 5651.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-April-2009 RFH
Synonyms(4-((2-Amino-4-bromophenyl)amino)-2-chlorophenyl)-(2-methylphenyl)methanone
DescriptionA cell-permeable aminobenzophenone compound that acts as a potent, ATP-binding pocket-targeting inhibitor against p38α and p38β2 (82% and 93% inhibition with 1 µM inhibitor, respectively; IC50 of p38α inhibition = 40 nM) with little activity against a panel of 57 other kinases, including p38γ, p38δ, Erk1/2, and JNK1. Shown to inhibit LPS-induced cytokine productions in human PBMC's in vitro and exhibit in vivo efficacy in both acute and chronic murine models of skin inflammation.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number321351-00-2
Chemical formulaC₂₀H₁₆BrClN₂O
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (50 mg/ml) or Ethanol (15 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesOttosen, E.R., et al. 2003. J. Med. Chem. 46, 5651.