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681525 Sigma-AldrichWiskostatin - CAS 253449-04-6 - Calbiochem

A cell-permeable N-alkylated carbazole derivative that selectively blocks actin filament assembly.

Wiskostatin - CAS 253449-04-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA
References
Data Sheet

Primary Target: N-WASP (neural Wiskott Aldrich syndrome protein)

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Overview

Key Spec Table

CAS #	Empirical Formula
253449-04-6	C₁₇H₁₈Br₂N₂O

Products

Catalogue Number	Packaging	Qty/Pack
681525-1MGCN	Plastic ampoule	1 mg	Add To Favorites Add To Favorites Added To My Favorites
681525-5MGCN	Plastic ampoule	5 mg	Add To Favorites Add To Favorites Added To My Favorites

Description
Overview	A cell-permeable N-alkylated carbazole derivative that selectively blocks actin filament assembly. Acts as a selective, reversible inhibitor of N-WASP (neural Wiskott Aldrich syndrome protein), a signal integrating protein. Appears to bind to N-WASP, stabilize the autoinhibited conformation and prevent the activation of Arp2/3 (actin-related protein 2/3) complex.
Catalogue Number	681525
Brand Family	Calbiochem®

References
References	Peterson, J.R., et al. 2004. Nat. Struct. Mol. Biol. 11, 747. Peterson, J.R., and Mitchison, T.J. 2002. Chem. Biol. 9, 1275.

Product Information
CAS number	253449-04-6
ATP Competitive	N
Form	White solid
Hill Formula	C₁₇H₁₈Br₂N₂O
Chemical formula	C₁₇H₁₈Br₂N₂O
Reversible	Y
Structure formula Image
Quality Level	MQ100

Biological Information
Primary Target	N-WASP (neural Wiskott Aldrich syndrome protein)
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Global Trade Item Number
Catalogue Number	GTIN
681525-1MGCN	04055977260090
681525-5MGCN	04055977260106

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