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14-594 VHR Protein, 10 µg

N-terminal GST-tagged, recombinant VHR expressed in E. coli, for use in Phosphatase Assays.

14-594
10 µg  Also available in 250 µg size --call for pricing and availability and reference catalog number 14-594M when ordering the 250 µg size.
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Catalogue Number14-594
Brand Family Upstate
Trade Name
  • Upstate
DescriptionVHR Protein, 10 µg
OverviewN-terminal GST-tagged, recombinant VHR expressed in E. coli
References
Product Information
Quality LevelMQ300
Applications
ApplicationN-terminal GST-tagged, recombinant VHR expressed in E. coli, for use in Phosphatase Assays.
Key Applications
  • Phosphatase Assay
Biological Information
Sourcerecombinant human full-length VHR expressed in E. coli
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene SummaryThe protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.
Gene Symbol
  • DUSP3
  • VHR
Protein TargetVHR
Purification MethodGlutathione-agarose
Target Sub-FamilySer/Thr/Tyr phosphatase
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P51452 # This protein shows activity both toward tyrosine-protein phosphate as well as with serine-protein phosphate.
SIZE: 185 amino acids; 20478 Da
SIMILARITY: SwissProt: P51452 ## Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. & Contains 1 tyrosine-protein phosphatase domain.
Molecular Weight47.8kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assuranceroutinely evaluated by phosphorylation of DiFMUP
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C
Packaging Information
Material Size10 µg
Material PackageAlso available in 250 µg size --call for pricing and availability and reference catalog number 14-594M when ordering the 250 µg size.
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
14-594 04053252328138

Documentation