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654380 Tunicamycin, Streptomyces lysosuperficus - CAS 11089-65-9 - Calbiochem

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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
11089-65-9C₃₉H₆₄N₄O₁₆

Products

Catalogue NumberPackaging Qty/Pack
654380-10MGCN Glass bottle 10 mg
654380-50MGCN Alu drum 50 mg
Description
OverviewA nucleoside antibiotic that inhibits N-linked glycosylation and blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against Gram-positive bacteria, yeasts, fungi, and viruses. Inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells. Also inhibits thrombin-induced Ca2+ mobilization in cells. Also available as a 25 mM solution in DMSO (Cat. No. 504570).
Catalogue Number654380
Brand Family Calbiochem®
References
ReferencesTordai, A., et al. 1995. Biochem. Biophys. Res. Commun. 206, 857.
Price, B.D., et al. 1992. J. Cell Physiol. 152, 545.
Product Information
CAS number11089-65-9
FormWhite to off-white solid
Hill FormulaC₃₉H₆₄N₄O₁₆
Chemical formulaC₃₉H₆₄N₄O₁₆
ReconstitutionAqueous solutions can be prepared from stock solutions in DMSO by diluting with H₂O at pH 8.0 to 10.0 or with appropriate buffers at pH >7.0 (preferably >8.0).
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
Biological Information
Primary TargetN-linked glycosylation
Secondary targetthrombin-induced Ca2+ mobilization in cells
Purity≥98% by HPLC (A+B+C+D)
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSYO7980200
Safety Information
R PhraseR: 26/27/28-60-61

Very toxic by inhalation, in contact with skin and if swallowed.
May impair fertility.
May cause harm to the unborn child.
S PhraseS: 22-36/37/39-45

Do not breathe dust.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Highly Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
654380-10MGCN 04055977184686
654380-50MGCN 04055977184693

Documentation

Tunicamycin, Streptomyces lysosuperficus - CAS 11089-65-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Tunicamycin, Streptomyces lysosuperficus - CAS 11089-65-9 - Calbiochem Certificates of Analysis

TitleLot Number
654380

References

Reference overview
Tordai, A., et al. 1995. Biochem. Biophys. Res. Commun. 206, 857.
Price, B.D., et al. 1992. J. Cell Physiol. 152, 545.

Citations

Title
  • Ray S. Oh, Xinli Bai and Johanna M. Rommens. (2006) Human homologs of UbC6P ubiquitin-conjugating enzyme and phosphorylation of HSUbC6E in response to endoplasmic reticulum stress. Journal of Biological Chemistry 281, 21480-21490.
  • Wolfdieter Springer, et al. (2005) A Caenorhabditis elegans Parkin mutant with altered solubility couples α-synuclein aggregation to proteotoxic stress. Human Molecular Genetics 14, 3407-3423.
  • Jenny J.L. Ho, et al. (2003) N-glycosylation is required for the surface localization of MUC17 mucin. 23, 585-592.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision19-September-2007 RFH
    DescriptionA nucleoside antibiotic that inhibits N-linked glycosylation and blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against gram-positive bacteria, yeasts, fungi, and viruses. Inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells. Also inhibits thrombin-induced Ca2+ mobilization in cells.
    FormWhite to off-white solid
    CAS number11089-65-9
    RTECSYO7980200
    Chemical formulaC₃₉H₆₄N₄O₁₆
    Structure formulaStructure formula
    Purity≥98% by HPLC (A+B+C+D)
    SolubilityDMSO (10 mg/ml), DMF, or Pyridine. Aqueous solutions can be prepared from DMSO stock solutions by diluting in H₂O at pH 8.0 to 10.0 or with appropriate buffers at pH >7.0.
    Storage +15°C to +30°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
    Toxicity Highly Toxic & Carcinogenic / Teratogenic
    Merck USA index14, 9819
    ReferencesTordai, A., et al. 1995. Biochem. Biophys. Res. Commun. 206, 857.
    Price, B.D., et al. 1992. J. Cell Physiol. 152, 545.
    Citation
  • Ray S. Oh, Xinli Bai and Johanna M. Rommens. (2006) Human homologs of UbC6P ubiquitin-conjugating enzyme and phosphorylation of HSUbC6E in response to endoplasmic reticulum stress. Journal of Biological Chemistry 281, 21480-21490.
  • Wolfdieter Springer, et al. (2005) A Caenorhabditis elegans Parkin mutant with altered solubility couples α-synuclein aggregation to proteotoxic stress. Human Molecular Genetics 14, 3407-3423.
  • Jenny J.L. Ho, et al. (2003) N-glycosylation is required for the surface localization of MUC17 mucin. 23, 585-592.
    		•