654164 Sigma-AldrichTubulin Polymerization Inhibitor II
The Tubulin Polymerization Inhibitor II, also referenced under CAS 1151995-69-5, acts as an effective anti-microtubule agent. This small molecule/inhibitor is primarily used for Cell Structure applications.
More>> The Tubulin Polymerization Inhibitor II, also referenced under CAS 1151995-69-5, acts as an effective anti-microtubule agent. This small molecule/inhibitor is primarily used for Cell Structure applications. Less<<Tubulin Polymerization Inhibitor II MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: (E)-1,3-Dihydro-6-methoxy-3-(3,4,5-trimethoxybenzylidene)-1H-indol-2-one
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 1151995-69-5 | C₁₉H₁₉NO₅ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
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| 654164-5MGCN | Plastic ampoule | 5 mg |
| Description | |
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| Overview | A cell-permeable, SU5416- (Cat. Nos. 676487 and 676498) derived combretastatin A-4 (Cat. No. 234200) analog that acts as an effective anti-microtubule agent (IC50 = 4.5 µM in inhibiting polymerization of purified porcine brain tubulin) and displays extremely potent anti-proliferative activity towards various cancer cell lines (GI50 <10 nM for 46 lines among a 53 NCI panel tested). |
| Catalogue Number | 654164 |
| Brand Family | Calbiochem® |
| Synonyms | (E)-1,3-Dihydro-6-methoxy-3-(3,4,5-trimethoxybenzylidene)-1H-indol-2-one |
| References | |
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| References | Pandit, B., et al. 2006. Bioorg. Med. Chem. 14, 6492. Li, P.K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5382. |
| Product Information | |
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| CAS number | 1151995-69-5 |
| ATP Competitive | N |
| Form | Yellow solid |
| Hill Formula | C₁₉H₁₉NO₅ |
| Chemical formula | C₁₉H₁₉NO₅ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | Purified porcine brain tubulin |
| Primary Target IC<sub>50</sub> | 4.5 µM in inhibiting polymerization of purified porcine brain tubulin |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 654164-5MGCN | 04055977184587 |
Documentation
Tubulin Polymerization Inhibitor II SDS
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Tubulin Polymerization Inhibitor II Certificates of Analysis
| Title | Lot Number |
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| 654164 |
References
| Reference overview |
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| Pandit, B., et al. 2006. Bioorg. Med. Chem. 14, 6492. Li, P.K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5382. |