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612200 Tissue Plasminogen Activator, Human

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612200
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Overview

Products

Catalogue NumberPackaging Qty/Pack
612200-100UGCN Plastic ampoule 100 μg
612200-1MGCN Glass bottle 1 mg
Description
OverviewNative tissue plasminogen activator from a human melanoma cell line. A serine protease that contains a single chain of 527 amino acids. Binds to fibrin via lysine binding sites at its amino terminus and activates bound plasminogen. Cleaves plasminogen to form active plasmin, the proteolytic enzyme that dissolves clots. Reported to be involved in neurite outgrowth, regeneration, and migration. Plays an important role in excitotoxin-induced neuronal degeneration.
Catalogue Number612200
Brand Family Calbiochem®
SynonymstPA
References
ReferencesKim, Y.H., et al. 1999. Science 284, 647.
Tsirka, S.E., et al. 1995. Nature 377, 340.
Winther, K., et al. 1992. J. Cardiovasc. Pharmacol. 19, S21.
Product Information
FormLyophilized
FormulationLyophilized from 100 mM PBS, 3.5 mg/ml L-arginine, 0.001% Tween®-80 Detergent.
Quality LevelMQ100
Biological Information
Purity≥95% by SDS-PAGE
SourcePrepared from cell line that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Specific Activity≥300 KU/mg protein
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Global Trade Item Number
Catalogue Number GTIN
612200-100UGCN 04055977187762
612200-1MGCN 04055977187755