616521 Sigma-AldrichTRPV4 Antagonist II, HC-067047 - CAS 883031-03-6 - Calbiochem
The TRPV4 Antagonist II, HC-067047 controls the biological activity of TRPV4.
More>> The TRPV4 Antagonist II, HC-067047 controls the biological activity of TRPV4. Less<<Synonyms: 2-Methyl-1-(3-morpholinopropyl)-5-phenyl-N-(3-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxamide, Transient Receptor Potential Vanilloid-4 Antagonist II, HC067047
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Overview
Key Spec Table
CAS # | Empirical Formula |
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883031-03-6 | C₂₆H₂₈F₃N₃O₂ |
Products
Catalogue Number | Packaging | Qty/Pack | |
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616521-10MGCN | Glass bottle | 10 mg |
Description | |
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Overview | A pyrrolocarboxamide compound that potently antagonizes TRP (transient receptor potential) family cation channel TRPV4 activity (IC50 = 17, 48, and 133 nM, respectively, against mouse, human, or rat TRPV4 in whole cell voltage-gated current measurement) in a reversible manner, displaying much reduced potency against human ERG and TRPM8 (IC50 = 368 and 780 nM, respectively) and little or no activity toward hKv1.3, hTRPA1, hTRPC5, hTRPV1/2/3/6, mTRPM7, mTRPV2, or rKv1.2. HC-067047 is efficacious (10 mg/kg via i.p.) in reducing micturition (urination) frequency and increasing voided urine volume of mice and rats suffering from CPA- (Cat. No. 239785) induced cystitis in vivo. |
Catalogue Number | 616521 |
Brand Family | Calbiochem® |
Synonyms | 2-Methyl-1-(3-morpholinopropyl)-5-phenyl-N-(3-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxamide, Transient Receptor Potential Vanilloid-4 Antagonist II, HC067047 |
References | |
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References | Everaerts, W., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 19084. |
Product Information | |
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CAS number | 883031-03-6 |
Form | White solid |
Hill Formula | C₂₆H₂₈F₃N₃O₂ |
Chemical formula | C₂₆H₂₈F₃N₃O₂ |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
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Purity | ≥98% by HPLC |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Catalogue Number | GTIN |
616521-10MGCN | 04055977185256 |