613450 Sigma-AldrichTOFA - CAS 54857-86-2 - Calbiochem
A cell-permeable furoic acid compound that acts as a potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in the fatty acid biosynthesis.
More>> A cell-permeable furoic acid compound that acts as a potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in the fatty acid biosynthesis. Less<<Synonyms: 5-(Tetradecyloxy)-2-furoic acid
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Overview
Key Spec Table
CAS # | Empirical Formula |
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54857-86-2 | C₁₉H₃₂O₄ |
Products
Catalogue Number | Packaging | Qty/Pack | |
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613450-5MGCN | Plastic ampoule | 5 mg |
Description | |
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Overview | A cell-permeable furoic acid compound that acts as a potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in the fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner (IC50 = 4 µM in human breast cancer cell line MCF7). TOFA-induced reduction in malonyl-CoA is reported to off-set the effect of C75 (Cat. No. 341325) on food intake in fasted mice and on apoptosis in tumor cells. |
Catalogue Number | 613450 |
Brand Family | Calbiochem® |
Synonyms | 5-(Tetradecyloxy)-2-furoic acid |
Product Information | |
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CAS number | 54857-86-2 |
ATP Competitive | Y |
Form | Off-white solid |
Hill Formula | C₁₉H₃₂O₄ |
Chemical formula | C₁₉H₃₂O₄ |
Reversible | Y |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
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Primary Target | Acetyl-CoA carboxylase (ACC) |
Primary Target IC<sub>50</sub> | 4 µM inhibiting cellular fatty acid synthesis in human breast cancer cell line MCF7 |
Purity | ≥98% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Catalogue Number | GTIN |
613450-5MGCN | 04055977263787 |