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613450 TOFA - CAS 54857-86-2 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
54857-86-2C₁₉H₃₂O₄

Products

Catalogue NumberPackaging Qty/Pack
613450-5MGCN Plastic ampoule 5 mg
Description
OverviewA cell-permeable furoic acid compound that acts as a potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in the fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner (IC50 = 4 µM in human breast cancer cell line MCF7). TOFA-induced reduction in malonyl-CoA is reported to off-set the effect of C75 (Cat. No. 341325) on food intake in fasted mice and on apoptosis in tumor cells.
Catalogue Number613450
Brand Family Calbiochem®
Synonyms5-(Tetradecyloxy)-2-furoic acid
References
ReferencesLandree, L.E., et al. 2004. J. Biol. Chem. 279, 3817.
Zhou, W., et al. 2003. Cancer Res. 63, 7330.
Hu, Z., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 12624.
Pizer, E.S., et al. 2000. Cancer Res. 60, 213.
Arbeeny, C.M., et al. 1992. J. Lipid Res. 33, 843.
Fukuda, N. and Ontko, J.A. 1984. J. Lipid Res. 25, 831.
Product Information
CAS number54857-86-2
ATP CompetitiveY
FormOff-white solid
Hill FormulaC₁₉H₃₂O₄
Chemical formulaC₁₉H₃₂O₄
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetAcetyl-CoA carboxylase (ACC)
Primary Target IC<sub>50</sub>4 µM inhibiting cellular fatty acid synthesis in human breast cancer cell line MCF7
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
613450-5MGCN 04055977263787