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530959 TAZ Activity Modulator, TM-25659 - CAS 260553-97-7 - Calbiochem

A cell-permeable enhancer of nuclear localization of transcriptional co-activator with PDZ-binding motif (TAZ). Does not affect the total amount of TAZ in pluripotent C3H10T1/2 cells.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: TM25659, TM 25659

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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
260553-97-7C₃₀H₂₈N₈

Products

Catalogue NumberPackaging Qty/Pack
5.30959.0001 Glass bottle 5 mg
Description
OverviewA cell permeable, orally bioavailable imidazol-[4,5-b]pyridine derivative that enhances nuclear localization of transcriptional co-activator with PDZ-binding motif (TAZ) in a dose-dependent manner without affecting the total amount of TAZ in pluripotent C3H10T1/2 cells. Does not affect Ser89 phosphorylation in TAZ, but reduces tyrosine phosphorylation. Reduces PPARg levels in differentiated adipocytes and acts as a suppressor of PPARg-dependent adipocyte differentiation. Also shown to enhance RUNX2-induced osteoblast differentiation of C3H10T1/2 cells and mineralization in a dose-dependent manner. Reduces weight gain in ob/ob mice (50 mg/kg, i.p.) and attenuates bone loss in ovariectomized mice. Displays desirable pharmacokinetic properties with t1/2 = 9.85 h.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number530959
Brand Family Calbiochem®
SynonymsTM25659, TM 25659
References
ReferencesJang, E.J., et al. 2012. Br. J. Pharmacol. 165, 1584.
Product Information
CAS number260553-97-7
FormYellow powder
Hill FormulaC₃₀H₂₈N₈
Chemical formulaC₃₀H₂₈N₈
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5.30959.0001 04055977283259

Documentation

TAZ Activity Modulator, TM-25659 - CAS 260553-97-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Jang, E.J., et al. 2012. Br. J. Pharmacol. 165, 1584.

Technical Info

Title
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White Paper: Further considerations of antibody validation and usage.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-March-2015 JSW
SynonymsTM25659, TM 25659
DescriptionA cell permeable, orally bioavailable imidazol-pyrimidine derivative that enhances nuclear localization of transcriptional co-activator with PDZ-binding motif (TAZ) in a dose-dependent manner without affecting the total amount of TAZ in pluripotent C3H10T1/2 cells. Does not affect Ser89 phosphorylation in TAZ, but reduces tyrosine phosphorylation. Reduces PPARg levels in differentiated adipocytes and acts as a suppressor of PPARg-dependent adipocyte differentiation. Also shown to enhance RUNX2-induced osteoblast differentiation of C3H10T1/2 cells and mineralization in a dose-dependent manner. Reduces weight gain in ob/ob mice (50 mg/kg, i.p.) and attenuates bone loss in ovariectomized mice. Displays desirable pharmacokinetic properties with t1/2 = 9.85 h.
FormYellow powder
Intert gas (Yes/No) Packaged under inert gas
CAS number260553-97-7
Chemical formulaC₃₀H₂₈N₈
Purity≥97% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesJang, E.J., et al. 2012. Br. J. Pharmacol. 165, 1584.