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579050 TAPI-0 - CAS 143457-40-3 - Calbiochem

TAPI-0, CAS 143457-40-3, is a hydroxamate-based inhibitor of collagenase, gelatinase, and TACE (TNF-α converting enzyme/ADAM17; IC₅₀ = 100 nM).

TAPI-0 - CAS 143457-40-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine Amide, TNF-α Protease Inhibitor-0

Primary Target: TNF-α converting enzyme/ADAM17
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
143457-40-3C₂₄H₃₂N₄O₅

Products

Catalogue NumberPackaging Qty/Pack
579050-1MGCN Plastic ampoule 1 mg
Description
OverviewA hydroxamate-based inhibitor of collagenase, gelatinase, and TACE (TNF-α converting enzyme/ADAM17; IC50 = 100 nM). Blocks spontaneous and PMA-induced release of TNF-α in transfected COS 7 cells.
Catalogue Number579050
Brand Family Calbiochem®
SynonymsN-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine Amide, TNF-α Protease Inhibitor-0
References
ReferencesHooper, N.M., et al. 1997. Biochem. J. 321, 265.
Mullberg, J., et al. 1995. J. Immunol. 155, 5198.
Mohler, K.M., et al. 1994. Nature 370, 218.
Product Information
CAS number143457-40-3
ATP CompetitiveN
DeclarationManufactured exclusively by Peptides International, Louisville, Kentucky, USA.
FormWhite solid
Hill FormulaC₂₄H₃₂N₄O₅
Chemical formulaC₂₄H₃₂N₄O₅
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetTNF-α converting enzyme/ADAM17
Primary Target IC<sub>50</sub>100 nM against TACE (TNF-α converting enzyme/ADAM17)
Purity≥96% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
579050-1MGCN 04055977265354

Documentation

TAPI-0 - CAS 143457-40-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

TAPI-0 - CAS 143457-40-3 - Calbiochem Certificates of Analysis

TitleLot Number
579050

References

Reference overview
Hooper, N.M., et al. 1997. Biochem. J. 321, 265.
Mullberg, J., et al. 1995. J. Immunol. 155, 5198.
Mohler, K.M., et al. 1994. Nature 370, 218.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-April-2008 RFH
SynonymsN-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine Amide, TNF-α Protease Inhibitor-0
DescriptionA hydroxymate-based inhibitor of collagenase, gelatinase, and TACE [(TNF-α convertase; ADAM17 (IC50 = 100 nM)]. Blocks spontaneous and PMA-induced release of TNF-α from transfected COS-7 cells.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number143457-40-3
Chemical formulaC₂₄H₃₂N₄O₅
Structure formulaStructure formula
Purity≥96% by HPLC
Solubility50% acetic acid (1 mg/ml) or DMSO (5 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesHooper, N.M., et al. 1997. Biochem. J. 321, 265.
Mullberg, J., et al. 1995. J. Immunol. 155, 5198.
Mohler, K.M., et al. 1994. Nature 370, 218.