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574776 Swinholide A, Theonella swinhoei - CAS 95927-67-6 - Calbiochem

A dimeric dilactone macrolide that is cytotoxic to a variety of cancer cell lines in vitro.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Disrupts the actin cytoskeleton
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
95927-67-6C₇₈H₁₃₂O₂₀

Products

Catalogue NumberPackaging Qty/Pack
574776-10UGCN Plastic ampoule 10 μg
Description
OverviewA dimeric dilactone macrolide that is cytotoxic to a variety of cancer cell lines in vitro. Disrupts the actin cytoskeleton by sequestering actin dimers with a binding stoichiometry of 1:1, and rapidly severing F-actin. Also possesses antifungal properties.
Catalogue Number574776
Brand Family Calbiochem®
References
ReferencesSaito, S.Y., et al. 1998. J. Biochem. (Tokyo) 123, 571.
Bubb, M.R., et al. 1995. J. Biol. Chem. 270, 3463.
Kobayashi, M., et al. 1994. Chem. Pharm. Bull. 42, 19.
Doi, M., et al. 1991. J. Org. Chem. 56, 3629.
Product Information
CAS number95927-67-6
ATP CompetitiveN
FormColorless oil
Hill FormulaC₇₈H₁₃₂O₂₀
Chemical formulaC₇₈H₁₃₂O₂₀
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetDisrupts the actin cytoskeleton
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
574776-10UGCN 04055977189728

Documentation

Swinholide A, Theonella swinhoei - CAS 95927-67-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Swinholide A, Theonella swinhoei - CAS 95927-67-6 - Calbiochem Certificates of Analysis

TitleLot Number
574776

References

Reference overview
Saito, S.Y., et al. 1998. J. Biochem. (Tokyo) 123, 571.
Bubb, M.R., et al. 1995. J. Biol. Chem. 270, 3463.
Kobayashi, M., et al. 1994. Chem. Pharm. Bull. 42, 19.
Doi, M., et al. 1991. J. Org. Chem. 56, 3629.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-September-2008 RFH
DescriptionA dimeric dilactone macrolide isolated from the marine sponge Theonella swinhoei. Cytotoxic to a variety of cancer cell lines in vitro. Disrupts the actin cytoskeleton by sequestering actin dimers with a binding stoichiometry of 1:1, and rapidly severing F-actin. Also possesses antifungal activity.
FormColorless oil
Intert gas (Yes/No) Packaged under inert gas
CAS number95927-67-6
Chemical formulaC₇₈H₁₃₂O₂₀
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityEthanol or acetone
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSaito, S.Y., et al. 1998. J. Biochem. (Tokyo) 123, 571.
Bubb, M.R., et al. 1995. J. Biol. Chem. 270, 3463.
Kobayashi, M., et al. 1994. Chem. Pharm. Bull. 42, 19.
Doi, M., et al. 1991. J. Org. Chem. 56, 3629.