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567731 Sphingosine Kinase Inhibitor - CAS 1177741-83-1 - Calbiochem

The Sphingosine Kinase Inhibitor, also referenced under CAS 1177741-83-1, controls the biological activity of Sphingosine Kinase. This small molecule/inhibitor is primarily used for Cell Signaling applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(p-Hydroxyanilino)-4-(p-chlorophenyl) thiazole, HCl, SK Inhibitor I

Primary Target: GST-hsk
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567731
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1177741-83-1C₁₅H₁₁ClN₂OS • HCl

Products

Catalogue NumberPackaging Qty/Pack
567731-10MGCN Plastic ampoule 10 mg
Description
OverviewA cell-permeable disubstituted thiazole compound that displays anti-tumor properties. Acts as a potent, substrate competitive, reversible, and highly specific inhibitor of sphingosine kinase (IC50 = 0.5 µM for GST-hSK). Does not affect the kinase activity of hERK2, hPI3K, or PKCα even at concentrations as high as 60 µM. Induces apoptosis in human cancer cells that express the drug transport proteins Pgp or MRP1 (IC50 = ~ 1-5 µM) through inhibiting sphingosine-1-phosphate production.
Catalogue Number567731
Brand Family Calbiochem®
Synonyms2-(p-Hydroxyanilino)-4-(p-chlorophenyl) thiazole, HCl, SK Inhibitor I
References
ReferencesFrench, K.J., et al. 2003. Cancer Res. 63, 5962.
Product Information
CAS number1177741-83-1
ATP CompetitiveY
FormWhite solid
Hill FormulaC₁₅H₁₁ClN₂OS • HCl
Chemical formulaC₁₅H₁₁ClN₂OS • HCl
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetGST-hsk
Primary Target IC<sub>50</sub>0.5 µM for GST-hSK
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
567731-10MGCN 07790788051686

Documentation

Sphingosine Kinase Inhibitor - CAS 1177741-83-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Sphingosine Kinase Inhibitor - CAS 1177741-83-1 - Calbiochem Certificates of Analysis

TitleLot Number
567731

References

Reference overview
French, K.J., et al. 2003. Cancer Res. 63, 5962.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-April-2011 RFH
Synonyms2-(p-Hydroxyanilino)-4-(p-chlorophenyl) thiazole, HCl, SK Inhibitor I
DescriptionA cell-permeable, potent non-ATP-competitive, reversible, and specific inhibitor of sphingosine kinase (IC50 = 500 nM for GST-hSK) that also exhibits anti-tumor properties. Does not affect the kinase activity of hERK2, hPI3 K, or PKCα at cocentrations as high as 60 µM. Shown to induce apoptosis in human cancer cells that express the drug transport proteins Pgp or MRP1 (IC50 ~1-5 µM) by inhibiting sphingosine-1-phosphate production.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1177741-83-1
Chemical formulaC₁₅H₁₁ClN₂OS • HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesFrench, K.J., et al. 2003. Cancer Res. 63, 5962.