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567540 Sodium Orthovanadate - CAS 13721-39-6 - Calbiochem

A broad spectrum potent inhibitor of protein tyrosine phosphatases.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PTP Inhibitor X

Primary Target: Na+,K+-ATPase, acid , alkaline phosphatases, phosphofructokinase, and adenylate kinase
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
13721-39-6Na₃VO₄

Products

Catalogue NumberPackaging Qty/Pack
567540-5GMCN Plastic ampoule 5 gm
Description
OverviewA broad spectrum potent inhibitor of protein tyrosine phosphatases. Also known to inhibit Na+,K+-ATPase, acid and alkaline phosphatases, phosphofructokinase, and adenylate kinase. Also inhibits the ATPase activity of the reconstituted binding protein-dependent ATP-Binding Cassette (ABC) transporter for maltose (MalFGK2) of Salmonella typhimurium in the micromolar range. Can be converted to pervanadate by hydrogen peroxide.
Catalogue Number567540
Brand Family Calbiochem®
SynonymsPTP Inhibitor X
References
ReferencesHuyer, G., et al. 1997. J. Biol. Chem. 272, 843.
Hunke, S., et al. 1995. Biochem. Biophys. Res. Commun. 216, 589.
Levchuck, S.G., et al. 1994. Pediatric Res. 37, 382A.
Fohr, K.J., et al. 1989. Biochem. J. 262, 83.
Swarup, G., et al. 1982. Biochem. Biophys. Res. Commun. 107, 1104.
Seargeant, L.E. and Stinson, R.A. 1979. Biochem. J. 181, 247.
Product Information
CAS number13721-39-6
ATP CompetitiveN
FormWhite to off-white solid
Hill FormulaNa₃VO₄
Chemical formulaNa₃VO₄
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetNa+,K+-ATPase, acid , alkaline phosphatases, phosphofructokinase, and adenylate kinase
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSYW1120000
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 22-36

Do not breathe dust.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
567540-5GMCN 04055977266689

Documentation

Sodium Orthovanadate - CAS 13721-39-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Sodium Orthovanadate - CAS 13721-39-6 - Calbiochem Certificates of Analysis

TitleLot Number
567540

References

Reference overview
Huyer, G., et al. 1997. J. Biol. Chem. 272, 843.
Hunke, S., et al. 1995. Biochem. Biophys. Res. Commun. 216, 589.
Levchuck, S.G., et al. 1994. Pediatric Res. 37, 382A.
Fohr, K.J., et al. 1989. Biochem. J. 262, 83.
Swarup, G., et al. 1982. Biochem. Biophys. Res. Commun. 107, 1104.
Seargeant, L.E. and Stinson, R.A. 1979. Biochem. J. 181, 247.

Brochure

Title
Protein Phosphatases Technical Bulletin

Citations

Title
  • Amit V. Pandey and Walter L. Miller. (2005) Regulation of 17,20 lyase activity by cytochrome b5 and by serine phosphorylation of P450c17. Journal of Biological Chemistry 280, 13265-13271.
  • Hendrik Ungefroren, et al. (2001) FAP-1 in pancreatic cancer cells: functional and mechanistic studies on its inhibitory role in CD95-mediated apoptosis. Journal of Cell Science 114, 2735-2746.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision10-October-2018 JSW
    SynonymsPTP Inhibitor X
    DescriptionA broad spectrum potent inhibitor of protein tyrosine phosphatases. Also known to inhibit Na+/K+ ATPase, acid and alkaline phosphatases, phosphofructokinase, and adenylate kinase. Most recently shown to inhibit ATPase activity of the reconstituted binding protein-dependent ATP-Binding Cassette (ABC) transporter for maltose (MalFGK2) of Salmonella typhimurium in the micromolar range. Can be converted to pervanadate by hydrogen peroxide.
    FormWhite to off-white solid
    CAS number13721-39-6
    RTECSYW1120000
    Chemical formulaNa₃VO₄
    SolubilityH₂O (10 mg/ml)
    Storage +15°C to +30°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    Toxicity Harmful
    ReferencesHuyer, G., et al. 1997. J. Biol. Chem. 272, 843.
    Hunke, S., et al. 1995. Biochem. Biophys. Res. Commun. 216, 589.
    Levchuck, S.G., et al. 1994. Pediatric Res. 37, 382A.
    Fohr, K.J., et al. 1989. Biochem. J. 262, 83.
    Swarup, G., et al. 1982. Biochem. Biophys. Res. Commun. 107, 1104.
    Seargeant, L.E. and Stinson, R.A. 1979. Biochem. J. 181, 247.
    Citation
  • Amit V. Pandey and Walter L. Miller. (2005) Regulation of 17,20 lyase activity by cytochrome b5 and by serine phosphorylation of P450c17. Journal of Biological Chemistry 280, 13265-13271.
  • Hendrik Ungefroren, et al. (2001) FAP-1 in pancreatic cancer cells: functional and mechanistic studies on its inhibitory role in CD95-mediated apoptosis. Journal of Cell Science 114, 2735-2746.
    		•