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573103 STAT3 Inhibitor VII - CAS 1041438-68-9 - Calbiochem

The STAT3 Inhibitor VII, also referenced under CAS 1041438-68-9, controls the biological activity of STAT3.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Ethyl-1-(4-cyano-2,3,5,6-tetrafluorophenyl)-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate

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573103
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1041438-68-9C₁₉H₇F₇N₂O₃

Products

Catalogue NumberPackaging Qty/Pack
573103-5MGCN Glass bottle 5 mg
Description
OverviewA cell-permeable dihydroquinoline compound that potently and specifically inhibits cellular JAK1/JAK2/TYK2/STAT3 activation (IC50 against U266 constitutive STAT3 Y705 phosphorylation =170 nM) as well as the transcription of STAT3 target genes, while exhibiting little effects against pathways involved in Akt/mTOR, Erk1/2, or STAT5 activation. Since the inhibitor does not affect JAK1/2/3 kinase activity, its cellular target(s) appears to be upstream of JAKs.
Catalogue Number573103
Brand Family Calbiochem®
SynonymsEthyl-1-(4-cyano-2,3,5,6-tetrafluorophenyl)-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate
References
ReferencesXu, J., et al. 2008. J. Med. Chem. 51, 4115.
Product Information
CAS number1041438-68-9
FormWhite to light orange solid
Hill FormulaC₁₉H₇F₇N₂O₃
Chemical formulaC₁₉H₇F₇N₂O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
573103-5MGCN 04055977266443

Documentation

STAT3 Inhibitor VII - CAS 1041438-68-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

STAT3 Inhibitor VII - CAS 1041438-68-9 - Calbiochem Certificates of Analysis

TitleLot Number
573103

References

Reference overview
Xu, J., et al. 2008. J. Med. Chem. 51, 4115.

Technical Info

Title
JAK/STAT Signaling Research Focus
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-December-2023 JSW
SynonymsEthyl-1-(4-cyano-2,3,5,6-tetrafluorophenyl)-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate
DescriptionA cell-permeable dihydroquinoline compound that potently and specifically inhibits cellular JAK1/JAK2/TYK2/STAT3 activation (IC50 against U266 constitutive STAT3 Y705 phosphorylation =170 nM) as well as the transcription of STAT3 target genes, while exhibiting little effects against pathways involved in Akt/mTOR, Erk1/2, or STAT5 activation. Since the inhibitor does not affect JAK1/2/3 kinase activity, its cellular target(s) appears to be upstream of JAKs.
FormWhite to light orange solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1041438-68-9
Chemical formulaC₁₉H₇F₇N₂O₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesXu, J., et al. 2008. J. Med. Chem. 51, 4115.