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557330 Rolipram - CAS 61413-54-5 - Calbiochem

A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC₅₀ = 800 nM).

Rolipram - CAS 61413-54-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone

Primary Target: PDE IV
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
61413-54-5C₁₆H₂₁NO₃

Products

Catalogue NumberPackaging Qty/Pack
557330-5MGCN Plastic ampoule 5 mg
Description
OverviewA cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC50 = 800 nM). A rolipram-insensitive PDE IV subtype is also known to exist. Also inhibits NF-κB and NFAT activation in Jurkat and primary T cells.
Catalogue Number557330
Brand Family Calbiochem®
Synonyms4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
References
ReferencesNavarro, J., et al. 1998. J. Virol. 72, 4712.
Truong, V.H. and Muller, T. 1994. FEBS Lett. 353, 113.
Underwood, D.C., et al. 1994. J. Pharmacol. Exp. Ther. 270, 250.
Moore, J.B., Jr., et al. 1991. Biochem. Pharmacol. 42, 679.
Reeves, M.L., et al. 1987. Biochem. J. 241, 535.
Schneider, H.H., et al. 1986. Eur. J. Pharmacol. 127, 105.
Product Information
CAS number61413-54-5
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₆H₂₁NO₃
Chemical formulaC₁₆H₂₁NO₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPDE IV
Primary Target IC<sub>50</sub>800 nM against cAMP-specific phosphodiesterase (PDE IV)
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSUY5749237
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
557330-5MGCN 04055977267945

Documentation

Rolipram - CAS 61413-54-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Rolipram - CAS 61413-54-5 - Calbiochem Certificates of Analysis

TitleLot Number
557330

References

Reference overview
Navarro, J., et al. 1998. J. Virol. 72, 4712.
Truong, V.H. and Muller, T. 1994. FEBS Lett. 353, 113.
Underwood, D.C., et al. 1994. J. Pharmacol. Exp. Ther. 270, 250.
Moore, J.B., Jr., et al. 1991. Biochem. Pharmacol. 42, 679.
Reeves, M.L., et al. 1987. Biochem. J. 241, 535.
Schneider, H.H., et al. 1986. Eur. J. Pharmacol. 127, 105.

Brochure

Title
Activators and Inhibitors of Adenylate Cyclase Technical Bulletin
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-June-2008 JSW
Synonyms4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
DescriptionCell permeable, selective competitive inhibitor of cAMP-specific phosphodiesterase IV (IC50 = 800 nM). Rolipram does not inhibit PDE I or PDE II, even at concentrations as high as 100 µM. It is only a weak inhibitor of PDE III (IC50 = 100 µM). A rolipram-insensitive phosphodiesterase IV subtype is also known to exist.
FormWhite solid
CAS number61413-54-5
RTECSUY5749237
Chemical formulaC₁₆H₂₁NO₃
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
Merck USA index14, 8251
ReferencesNavarro, J., et al. 1998. J. Virol. 72, 4712.
Truong, V.H. and Muller, T. 1994. FEBS Lett. 353, 113.
Underwood, D.C., et al. 1994. J. Pharmacol. Exp. Ther. 270, 250.
Moore, J.B., Jr., et al. 1991. Biochem. Pharmacol. 42, 679.
Reeves, M.L., et al. 1987. Biochem. J. 241, 535.
Schneider, H.H., et al. 1986. Eur. J. Pharmacol. 127, 105.