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553509 Ras/Rac Transformation Blocker, SCH 51344 - CAS 171927-40-5 - Calbiochem

Ras/Rac Transformation Blocker, SCH 51344, CAS 171927-40-5, is a blocker of Ras-induced malignant transformation & Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II complex.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 6-Methoxy-4-(2-((2-hydroxyethoxyl)-ethyl)amino)-3-methyl-1H-pyrazolo[3,4-b]quinoline

Primary Target: Ras/Rac
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Overview

Key Spec Table

CAS #Empirical Formula
171927-40-5C₁₆H₂₀N₄O₃

Products

Catalogue NumberPackaging Qty/Pack
553509-10MGCN Plastic ampoule 10 mg
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Description
OverviewA cell-permeable pyrazoloquinoline compound that acts as an effective blocker of Ras-induced malignant transformation and inhibits Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II complex and membrane ruffling. The effect of SCH 51344 is limited to Ras/Rac pathway(s) other than those involving ERK and JNK. Shown to directly target human mutT homolog MTH1/NUDT1 with a Kd of 49 nM and inhibit its catalytic activity (IC50 for pyrophosphate release during nucleotide triphosphate hydrolysis = 215, 410 and 675 nM against dGTP, 8-oxo-dGTP and 2-OH-dATP substrates, respectively).
Catalogue Number553509
Brand Family Calbiochem®
Synonyms6-Methoxy-4-(2-((2-hydroxyethoxyl)-ethyl)amino)-3-methyl-1H-pyrazolo[3,4-b]quinoline
References
ReferencesHuber, K. V. M., et al. 2014. Nature In press.
He, H., et al. 1998. Mol. Cell. Biol. 18, 3829.
Walsh, A.B., et al. 1997. Oncogene 15, 2553.
Chandra Kumar, C., et al. 1995. Cancer Res. 55, 5106.
Product Information
CAS number171927-40-5
ATP CompetitiveN
FormLight-yellow solid
Hill FormulaC₁₆H₂₀N₄O₃
Chemical formulaC₁₆H₂₀N₄O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationRas/Rac Transformation Blocker, SCH 51344, CAS 171927-40-5, is a blocker of Ras-induced malignant transformation & Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II complex.
Biological Information
Primary TargetRas/Rac
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
553509-10MGCN 04055977193688