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553014 Raf Kinase Inhibitor IV - CAS 303727-31-3 - Calbiochem

The Raf Kinase Inhibitor IV, also referenced under CAS 303727-31-3, controls the biological activity of Raf Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole, L 779450

Primary Target: Raf Kinase
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
303727-31-3C₂₀H₁₄ClN₃O

Products

Catalogue NumberPackaging Qty/Pack
553014-1MGCN Plastic ampoule 1 mg
Description
OverviewA cell-permeable triarylimidazole compound that acts as a reversible, ATP-competitive, and highly potent inhibitor of Raf kinase (IC50 = 10 nM and Kd = 2.4 nM for B-raf) with 7-, 30-, and 70-fold selectivity over p38α, GSK-3β, and Lck, respectively. Cellular data have indicated that the compound is more effective towards Raf-1and A-Raf than B-Raf.
Catalogue Number553014
Brand Family Calbiochem®
Synonyms2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole, L 779450
References
ReferencesTakle, A.K., et al. 2006. Bioorg. Med. Chem. Lett. 16, 378.
Shelton, J.G., et al. 2003. Leukemia 17, 1765.
Product Information
CAS number303727-31-3
ATP CompetitiveY
FormOff-white solid
Hill FormulaC₂₀H₁₄ClN₃O
Chemical formulaC₂₀H₁₄ClN₃O
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetRaf Kinase
Primary Target IC<sub>50</sub>10 nM; Kd = 2.4 nM for B-raf
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
553014-1MGCN 04055977193428

Documentation

Raf Kinase Inhibitor IV - CAS 303727-31-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Raf Kinase Inhibitor IV - CAS 303727-31-3 - Calbiochem Certificates of Analysis

TitleLot Number
553014

References

Reference overview
Takle, A.K., et al. 2006. Bioorg. Med. Chem. Lett. 16, 378.
Shelton, J.G., et al. 2003. Leukemia 17, 1765.

Posters

Title
Human Kinome & InhibitorSelect™ Libraries
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-May-2011 RFH
Synonyms2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole, L 779450
DescriptionA cell-permeable triarylimidazole compound that acts as a reversible, ATP-competitive, and highly potent inhibitor of Raf kinase (IC50 = 10 nM & Kd = 2.4 nM for B-raf) with 7-, 30-, and 70-fold selectivity over p38α, GSK-3β, and Lck, respectively. Cellular data have indicated that the compound is more effective towards Raf-1and A-Raf than B-Raf.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number303727-31-3
Chemical formulaC₂₀H₁₄ClN₃O
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (100 mg/ml) or EtOH (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesTakle, A.K., et al. 2006. Bioorg. Med. Chem. Lett. 16, 378.
Shelton, J.G., et al. 2003. Leukemia 17, 1765.