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528281 Polo-like Kinase Inhibitor IV, SBE13 - CAS 775294-82-1 - Calbiochem

The Polo-like Kinase Inhibitor IV, SBE13, also referenced under CAS 775294-82-1, controls the biological activity of Polo-like Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(4-((6-Chloro-3-pyridinyl)methoxy)-3-methoxybenzyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amine

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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
775294-82-1C₂₄H₂₇ClN₂O₄

Products

Catalogue NumberPackaging Qty/Pack
528281-10MGCN 10 mg
Description
OverviewA cell-permeable vanillin-derived pyridyl-ethanamine compound that acts as a highly potent type II Plk1 inhibitor (IC50 of 200 pM) and targets the less conserved DFG motif that is only accessible when the kinase is in its inactive DFG-out conformation, resulting in an excellent selectivity over Plk2 (IC50 >66 µM), Plk3 (IC50 = 875 nM), and aurora A kinase (no detectable effect). Shown to inhibit the proliferation of HeLa cells with an EC50 of 18 µM.
Catalogue Number528281
Brand Family Calbiochem®
SynonymsN-(4-((6-Chloro-3-pyridinyl)methoxy)-3-methoxybenzyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amine
References
ReferencesKeppner, S., et al. 2009. ChemMedChem. 4, 1806.
Product Information
CAS number775294-82-1
FormBeige solid
Hill FormulaC₂₄H₂₇ClN₂O₄
Chemical formulaC₂₄H₂₇ClN₂O₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥94% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
528281-10MGCN 04055977196566

Documentation

Polo-like Kinase Inhibitor IV, SBE13 - CAS 775294-82-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Polo-like Kinase Inhibitor IV, SBE13 - CAS 775294-82-1 - Calbiochem Certificates of Analysis

TitleLot Number
528281

References

Reference overview
Keppner, S., et al. 2009. ChemMedChem. 4, 1806.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-April-2011 RFH
SynonymsN-(4-((6-Chloro-3-pyridinyl)methoxy)-3-methoxybenzyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amine
DescriptionA cell-permeable vanillin-derived pyridyl-ethanamine compound that acts as a highly potent type II Plk1 inhibitor (IC50 of 200 pM) and targets the less conserved DFG motif that is only accessible when the kinase is in its inactive DFG-out conformation, resulting in an excellent selectivity over Plk2 (IC50 >66 µM), Plk3 (IC50 = 875 nM), and aurora A kinase (no detectable effect). Shown to inhibit the proliferation of HeLa cells with an EC50 of 18 µM.
FormBeige solid
Intert gas (Yes/No) Packaged under inert gas
CAS number775294-82-1
Chemical formulaC₂₄H₂₇ClN₂O₄
Structure formulaStructure formula
Purity≥94% by HPLC
SolubilityDMSO (25 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesKeppner, S., et al. 2009. ChemMedChem. 4, 1806.