Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

529581 PP1 Analog II, 1NM-PP1 - CAS 221244-14-0 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
221244-14-0C₂₀H₂₁N₅

Products

Catalogue NumberPackaging Qty/Pack
529581-1MGCN Glass bottle 1 mg
Description
OverviewA cell-permeable and reversible PP1 analog (Cat. No. 529579) that acts as a potent and selective ATP-competitive inhibitor of mutant kinases over wild-type (IC50 = 3.2 nM for T339G, c-Fyn-as1 vs. 1.0 µM for c-Fyn; 4.3 nM for I338G, v-src-as1 vs. 28 µM for v-src; 5 nM for F80G, CDK2-as1 vs. 29 µM for CDK2; 8 nM for F89G, CAMK IIα-as1 vs. 24 µM for CAMKII; 120 nM for T315A, c-Abl-as2 vs. 3.4 µM for c-Abl). Shown to activate mutants of Ire1, a transmembrane kinase. Also available as a 10 mM solution in DMSO (Cat. No. 529606).
Catalogue Number529581
Brand Family Calbiochem®
SynonymsMutant Kinases Inhibitor II, 4-Amino-1-tert-butyl-3-(1ʹ-naphthylmethyl)pyrazolo[3,4-d]pyrimidine, NM
References
ReferencesIra, G., et al. 2004. Nature 431, 1011.
Papa, F.R., et al. 2003. Science 302, 1533.
Bishop, A.C., et al. 2000. Nature 407, 395.
Weiss, E.L., et al. 2000. Nat. Cell Biol. 2, 677.
Bishop, A.C., et al. 1999. J. Am. Chem. Soc. 121, 627.
Product Information
CAS number221244-14-0
ATP CompetitiveY
FormWhite solid
Hill FormulaC₂₀H₂₁N₅
Chemical formulaC₂₀H₂₁N₅
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetT339G
Primary Target IC<sub>50</sub>3.2 nM for T339G, c-Fyn-as1 vs. 1.0 µM for c-Fyn; 4.3 nM for I338G, v-src-as1 vs. 28 µM for v-src; 5 nM for F80G, CDK2-as1 vs. 29 µM for CDK2; 8 nM for F89G, CAMK IIα-as1 vs. 24 µM for CAMKII; 120 nM for T315A, c-Abl-as2 vs.
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
529581-1MGCN 04055977269871