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527450 PKR Inhibitor - CAS 608512-97-6 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
608512-97-6C₁₃H₈N₄OS

Products

Catalogue NumberPackaging Qty/Pack
527450-5MGCN Glass bottle 5 mg
Description
OverviewAn imidazolo-oxindole compound that acts as a potent, ATP-binding site directed inhibitor of PKR. Shown to effectively inhibit RNA-induced PKR autophosphorylation (IC50 = 210 nM) and rescue PKR-dependent translation block (IC50 = 100 nM). Inactive control is also available (Cat. No. 527455). Shown to increase the late phase of long-lasting synaptic potentiation, and enhance long-term memory in mice. Also available as a 50 mM solution in DMSO (Cat. No. 527451).
Catalogue Number527450
Brand Family Calbiochem®
SynonymsDouble-stranded RNA-dependent Protein Kinase Inhibitor, PKRi, C16, Double-stranded RNA-activated Protein Kinase Inhibitor I, EIF2AK2 Inhibitor I
References
ReferencesZhu, P.J., et al. 2011. Cell 147, 1384.
Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50.
Product Information
CAS number608512-97-6
ATP CompetitiveN
FormOrange to orange brown solid
Hill FormulaC₁₃H₈N₄OS
Chemical formulaC₁₃H₈N₄OS
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationPKR Inhibitor, CAS 608512-97-6, is a potent, ATP-binding site directed PKR inhibitor that blocks RNA-induced PKR autophosphorylation (IC50 = 210 nM). Rescue PKR-dependent translation block.
Biological Information
Primary TargetPKR
Primary Target IC<sub>50</sub>210 nM inhibiting RNA-induced PKR autophosphorylation and 100 nM in rescuing PKR-dependent translation block
Purity≥90% by HPLC
Physicochemical Information
Cell permeableN
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
527450-5MGCN 07790788055615