527450 Sigma-AldrichPKR Inhibitor - CAS 608512-97-6 - Calbiochem
PKR Inhibitor, CAS 608512-97-6, is a potent, ATP-binding site directed PKR inhibitor that blocks RNA-induced PKR autophosphorylation (IC50 = 210 nM). Rescue PKR-dependent translation block.
More>> PKR Inhibitor, CAS 608512-97-6, is a potent, ATP-binding site directed PKR inhibitor that blocks RNA-induced PKR autophosphorylation (IC50 = 210 nM). Rescue PKR-dependent translation block. Less<<PKR Inhibitor - CAS 608512-97-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: PKRi, Double-stranded RNA-dependent Protein Kinase Inhibitor, C16, Double-stranded RNA-activated Protein Kinase Inhibitor I, EIF2AK2 Inhibitor I
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 608512-97-6 | C₁₃H₈N₄OS |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 527450-5MGCN | Glass bottle | 5 mg |
| Description | |
|---|---|
| Overview | An imidazolo-oxindole compound that acts as a potent, ATP-binding site directed inhibitor of PKR. Shown to effectively inhibit RNA-induced PKR autophosphorylation (IC50 = 210 nM) and rescue PKR-dependent translation block (IC50 = 100 nM). Inactive control is also available (Cat. No. 527455). Shown to increase the late phase of long-lasting synaptic potentiation, and enhance long-term memory in mice. Also available as a 50 mM solution in DMSO (Cat. No. 527451). |
| Catalogue Number | 527450 |
| Brand Family | Calbiochem® |
| Synonyms | PKRi, Double-stranded RNA-dependent Protein Kinase Inhibitor, C16, Double-stranded RNA-activated Protein Kinase Inhibitor I, EIF2AK2 Inhibitor I |
| References | |
|---|---|
| References | Zhu, P.J., et al. 2011. Cell 147, 1384. Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50. |
| Product Information | |
|---|---|
| CAS number | 608512-97-6 |
| ATP Competitive | N |
| Form | Orange to orange brown solid |
| Hill Formula | C₁₃H₈N₄OS |
| Chemical formula | C₁₃H₈N₄OS |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | PKR |
| Primary Target IC<sub>50</sub> | 210 nM inhibiting RNA-induced PKR autophosphorylation and 100 nM in rescuing PKR-dependent translation block |
| Purity | ≥90% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | N |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 527450-5MGCN | 07790788055615 |