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539624 PKCζ Pseudosubstrate Inhibitor, Myristoylated - Calbiochem

PKCζ Pseudosubstrate Inhibitor is a myristoylated, cell-permeable, reversible, substrate competitive inhibitor of protein kinase Cζ.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Myr-SIYRRGARRWRKL-OH, Protein Kinase Cζ Pseudosubstrate Inhibitor, Myristoylated

Primary Target: insulin-stimulated transport in intact adinocytes
539624
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₉₀H₁₅₄N₃₀O₁₇

Products

Catalogue NumberPackaging Qty/Pack
539624-500UGCN Glass bottle 500 μg
Description
OverviewA cell-permeable, reversible, substrate competitive, myristoylated form of the protein kinase Cζ isozyme pseudosubstrate inhibitory (Cat. No. 539610).
Catalogue Number539624
Brand Family Calbiochem®
SynonymsMyr-SIYRRGARRWRKL-OH, Protein Kinase Cζ Pseudosubstrate Inhibitor, Myristoylated
References
ReferencesPowell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
Sajan, M.P., et al. 1999. J. Biol. Chem. 274, 30495.
Standaert, M.L., et al. 1999. J. Biol. Chem. 274, 14074.
Laudanna, C., et al. 1998. J. Biol. Chem. 273, 30306.
Standaert, M.L., et al. 1997. J. Biol. Chem. 272, 30075.
Product Information
ATP CompetitiveN
FormLyophilized
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₉₀H₁₅₄N₃₀O₁₇
Chemical formulaC₉₀H₁₅₄N₃₀O₁₇
Hygroscopic Hygroscopic
ReversibleY
Sold on the basis of peptide contentY
Quality LevelMQ100
Applications
Biological Information
Primary Targetinsulin-stimulated transport in intact adinocytes
Primary Target IC<sub>50</sub>EC50 = 10-20 µM against insulin-stimulated transport in intact adipocytes
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Peptide ContentY
Peptide SequenceMyr-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu-OH
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
539624-500UGCN 04055977194791

Documentation

PKCζ Pseudosubstrate Inhibitor, Myristoylated - Calbiochem Certificates of Analysis

TitleLot Number
539624

References

Reference overview
Powell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
Sajan, M.P., et al. 1999. J. Biol. Chem. 274, 30495.
Standaert, M.L., et al. 1999. J. Biol. Chem. 274, 14074.
Laudanna, C., et al. 1998. J. Biol. Chem. 273, 30306.
Standaert, M.L., et al. 1997. J. Biol. Chem. 272, 30075.

Citations

Title
  • Fishelevich, R., et al. 2006. Journal of Immunology 176, 2590.
  • Mason, J.C., et al. 2004. Journal of Biological Chemistry 279, 41611.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision11-January-2010 RFH
    SynonymsMyr-SIYRRGARRWRKL-OH, Protein Kinase Cζ Pseudosubstrate Inhibitor, Myristoylated
    DescriptionA cell-permeable, reversible, substrate competitive myristoylated form of protein kinase Cζ pseudo-substrate peptide (Cat. No. 539610) that includes amino acids 113-125 of the pseudosubstrate region. Useful for inhibition studies of PKCζ in intact cells. Reported to inhibit insulin-stimulated glucose transport in intact adipocytes (EC50 = 10-20 µM).
    FormLyophilized
    FormulationSupplied as a trifluoroacetate salt.
    Chemical formulaC₉₀H₁₅₄N₃₀O₁₇
    Peptide SequenceMyr-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu-OH
    Purity≥97% by HPLC
    SolubilityH₂O (2 mg/ml)
    Storage -20°C
    Hygroscopic
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    Toxicity Standard Handling
    ReferencesPowell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
    Sajan, M.P., et al. 1999. J. Biol. Chem. 274, 30495.
    Standaert, M.L., et al. 1999. J. Biol. Chem. 274, 14074.
    Laudanna, C., et al. 1998. J. Biol. Chem. 273, 30306.
    Standaert, M.L., et al. 1997. J. Biol. Chem. 272, 30075.
    Citation
  • Fishelevich, R., et al. 2006. Journal of Immunology 176, 2590.
  • Mason, J.C., et al. 2004. Journal of Biological Chemistry 279, 41611.
    		•