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116805 PKA Inhibitor 5-24 - CAS 99534-03-9 - Calbiochem

The PKA Inhibitor 5-24, also referenced under CAS 99534-03-9, controls the biological activity of PKA. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Protein Kinase A Inhibitor 5-24, H-TTYADFIASGRTGRRNAIHD, PKA Inhibitor IV

Primary Target: PKA
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116805
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
99534-03-9C₉₄H₁₄₈N₃₂O₃₁

Products

Catalogue NumberPackaging Qty/Pack
116805-500UGCN Plastic ampoule 500 μg
Description
OverviewA potent synthetic peptide that is a competitive inhibitor of protein kinase A (Ki = 2.3 nM). Its sequence is derived from the heat-stable skeletal muscle inhibitor protein of PKA. Binds to the catalytic subunit of PKA and displaces the regulatory subunit. Mimics the protein substrate by binding to the catalytic site via the arginine-cluster basic substrate.
Catalogue Number116805
Brand Family Calbiochem®
SynonymsProtein Kinase A Inhibitor 5-24, H-TTYADFIASGRTGRRNAIHD, PKA Inhibitor IV
References
ReferencesKnighton, D.R., et al. 1991. Science 253, 525.
Cheng, H.C., et al. 1986. J. Biol. Chem. 261, 989.
Rusine, T., et al. 1986. J. Cell Biol. 102, 1630.
Wong, Y.S., et al. 1986. J. Biol. Chem. 12089.
Product Information
CAS number99534-03-9
ATP CompetitiveN
FormLyophilized
FormulationSupplied as a trifluoroacetate salt. Sold on the basis of peptide content.
Hill FormulaC₉₄H₁₄₈N₃₂O₃₁
Chemical formulaC₉₄H₁₄₈N₃₂O₃₁
Hygroscopic Hygroscopic
ReversibleN
Sold on the basis of peptide contentY
Quality LevelMQ100
Applications
Biological Information
Primary TargetPKA
Primary Target K<sub>i</sub>2.3 nM for protein kinase A
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Peptide ContentY
Peptide SequenceH-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-OH
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
116805-500UGCN 04055977208214

Documentation

PKA Inhibitor 5-24 - CAS 99534-03-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

PKA Inhibitor 5-24 - CAS 99534-03-9 - Calbiochem Certificates of Analysis

TitleLot Number
116805

References

Reference overview
Knighton, D.R., et al. 1991. Science 253, 525.
Cheng, H.C., et al. 1986. J. Biol. Chem. 261, 989.
Rusine, T., et al. 1986. J. Cell Biol. 102, 1630.
Wong, Y.S., et al. 1986. J. Biol. Chem. 12089.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-April-2008 RFH
SynonymsProtein Kinase A Inhibitor 5-24, H-TTYADFIASGRTGRRNAIHD, PKA Inhibitor IV
DescriptionPeptide corresponding to the active site on the skeletal muscle inhibitor protein. Competitive inhibitor of protein kinase A (Ki = 2.3 nM).
FormLyophilized
FormulationSupplied as a trifluoroacetate salt. Sold on the basis of peptide content.
CAS number99534-03-9
Chemical formulaC₉₄H₁₄₈N₃₂O₃₁
Peptide SequenceH-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-OH
Purity≥95% by HPLC
SolubilityH₂O (1 mg/ml). Sonication or the addition of a few drops of dilute acid (10 mM HCl) may be necessary to achieve complete solubilization.
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Toxicity Standard Handling
ReferencesKnighton, D.R., et al. 1991. Science 253, 525.
Cheng, H.C., et al. 1986. J. Biol. Chem. 261, 989.
Rusine, T., et al. 1986. J. Cell Biol. 102, 1630.
Wong, Y.S., et al. 1986. J. Biol. Chem. 12089.