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526524 PIM1/2 Kinase Inhibitor VI - CAS 587852-28-6 - Calbiochem

The PIM1/2 Kinase Inhibitor VI, also referenced under CAS 587852-28-6, controls the biological activity of PIM1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (Z)-5-(4-Propoxybenzylidene)thiazolidine-2,4-dione, SMI-16a

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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
587852-28-6C₁₃H₁₃NO₃S

Products

Catalogue NumberPackaging Qty/Pack
526524-5MGCN Plastic ampoule 5 mg
Description
OverviewA cell-permeable thiazolidinedione compound that acts as a potent, ATP-competitive inhibitor against Pim-1/2 kinases (IC50 = 150 nM and 20 nM against Pim-1 and Pim-2, respectively) as well as DYRK1α (68% inhibition of DYRK1α and Pim-2 at 5 µM), while exhibiting little or no activity against a panel of 57 other kinases (≤18% inhibition at 5 µM). Reported to exhibit antitumor activity both in PC3 human prostate cancer cultures in vitro (IC50 = 48 µM) and in JC adenocarcinoma-transplanted Balb/C mice in vivo (~46% tumor mass reduction on day 20; 50 mg/kg via daily i.p.).
Catalogue Number526524
Brand Family Calbiochem®
Synonyms(Z)-5-(4-Propoxybenzylidene)thiazolidine-2,4-dione, SMI-16a
References
ReferencesXia, Z., et al. 2009. J. Med. Chem. 52, 74.
Product Information
CAS number587852-28-6
FormYellow solid
Hill FormulaC₁₃H₁₃NO₃S
Chemical formulaC₁₃H₁₃NO₃S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
526524-5MGCN 04055977270785

Documentation

PIM1/2 Kinase Inhibitor VI - CAS 587852-28-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

PIM1/2 Kinase Inhibitor VI - CAS 587852-28-6 - Calbiochem Certificates of Analysis

TitleLot Number
526524

References

Reference overview
Xia, Z., et al. 2009. J. Med. Chem. 52, 74.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-April-2011 RFH
Synonyms(Z)-5-(4-Propoxybenzylidene)thiazolidine-2,4-dione, SMI-16a
DescriptionA cell-permeable thiazolidinedione compound that acts as a potent, ATP-competitive inhibitor against Pim-1/2 kinases (IC50 = 150 nM and 20 nM against Pim-1 and Pim-2, respectively) as well as DYRK1α (68% inhibition of DYRK1α and Pim-2 at 5 µM), while exhibiting little or no activity against a panel of 57 other kinases (≤18% inhibition at 5 µM). Reported to exhibit antitumor activity both in PC3 human prostate cancer cultures in vitro (IC50 = 48 µM) and in JC adenocarcinoma-transplanted Balb/C mice in vivo (~46% tumor mass reduction on day 20; 50 mg/kg via daily i.p.).
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number587852-28-6
Chemical formulaC₁₃H₁₃NO₃S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (25 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesXia, Z., et al. 2009. J. Med. Chem. 52, 74.