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528110 PIH - CAS 737-86-0 - Calbiochem

A cell-permeable, non-toxic tridendate iron (Fe3+) chelator of the aroyl hydrazone class.

PIH - CAS 737-86-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: pyridoxal isonicotinoyl hydrazone, Iron Chelator III

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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
737-86-0C₁₄H₁₄N₄O₃

Products

Catalogue NumberPackaging Qty/Pack
528110-50MGCN Plastic ampoule 50 mg
Description
OverviewA cell-permeable, non-toxic tridendate iron (Fe3+) chelator of the aroyl hydrazone class. Even at low concentrations, highly effective in mobilizing Fe3+ from cells and preventing its uptake from transferrin, even at low concentrations. Exhibits similar specificity and binding affinity as Deferoxamine Mesylate (Cat. No. 252750) but has greater access to mitochondrial iron. Also useful for the management of iron overload disease in experimental models. Inhibits the induction of heme containing indoleamine 2,3-dioxygenase activity.
Catalogue Number528110
Brand Family Calbiochem®
Synonymspyridoxal isonicotinoyl hydrazone, Iron Chelator III
References
ReferencesBuss, J.L., et al. 2002. Biochem. Pharmacol. 64, 1689.
Thomas, S.R., et al. 2001. J. Immunol. 166, 6332.
Hermes-Linda, M., et al. 2000. Biochim. Biophys. Acta 1523, 154.
Blaha, K., et al. 1998. Blood 11, 4368.
Richardson, D.R., and Ponka, P. 1998. J. Lab. Clin. Med. 131, 306.
Richardson, D.R.,et al. 1995. Blood 86, 4295.
Richardson, D.R., et al. 1994. J. Lab. Clin. Med. 124, 660.
Ponka, P., et al. 1988. Biochim. Biophys. Acta 967, 122.
Ponka, P., et al. 1984. Biochim. Biophys. Acta 802, 477.
Ponka, P., et al. 1979. FEBS Lett. 97, 317.
Product Information
CAS number737-86-0
FormYellow solid
Hill FormulaC₁₄H₁₄N₄O₃
Chemical formulaC₁₄H₁₄N₄O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. Acidic stock solutions are stable for up to 2 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
528110-50MGCN 04055977270518

Documentation

PIH - CAS 737-86-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

PIH - CAS 737-86-0 - Calbiochem Certificates of Analysis

TitleLot Number
528110

References

Reference overview
Buss, J.L., et al. 2002. Biochem. Pharmacol. 64, 1689.
Thomas, S.R., et al. 2001. J. Immunol. 166, 6332.
Hermes-Linda, M., et al. 2000. Biochim. Biophys. Acta 1523, 154.
Blaha, K., et al. 1998. Blood 11, 4368.
Richardson, D.R., and Ponka, P. 1998. J. Lab. Clin. Med. 131, 306.
Richardson, D.R.,et al. 1995. Blood 86, 4295.
Richardson, D.R., et al. 1994. J. Lab. Clin. Med. 124, 660.
Ponka, P., et al. 1988. Biochim. Biophys. Acta 967, 122.
Ponka, P., et al. 1984. Biochim. Biophys. Acta 802, 477.
Ponka, P., et al. 1979. FEBS Lett. 97, 317.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-April-2008 RFH
Synonymspyridoxal isonicotinoyl hydrazone, Iron Chelator III
DescriptionA cell-permeable, non-toxic, iron (Fe3+) chelator of the aroyl hydrazone class that exhibits high chelation efficacy. Highly effective in mobilizing Fe3+ from cells and preventing its uptake from transferrin, even at low concentrations. Exhibits similar specificity and binding affinity as Desferrioxamine (Cat. No. 252750) but has greater access to mitochondrial iron. Prevents iron-mediated oxyradical formation and minimizes tissue damage. Reported to useful in studies of the management of iron overload disease. Inhibits the induction of heme-containing indoleamine 2,3-dioxygenase activity.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number737-86-0
Chemical formulaC₁₄H₁₄N₄O₃
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (5 mg/ml) or slightly acidic medium
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. Acidic stock solutions are stable for up to 2 months at -20°C.
Toxicity Standard Handling
ReferencesBuss, J.L., et al. 2002. Biochem. Pharmacol. 64, 1689.
Thomas, S.R., et al. 2001. J. Immunol. 166, 6332.
Hermes-Linda, M., et al. 2000. Biochim. Biophys. Acta 1523, 154.
Blaha, K., et al. 1998. Blood 11, 4368.
Richardson, D.R., and Ponka, P. 1998. J. Lab. Clin. Med. 131, 306.
Richardson, D.R.,et al. 1995. Blood 86, 4295.
Richardson, D.R., et al. 1994. J. Lab. Clin. Med. 124, 660.
Ponka, P., et al. 1988. Biochim. Biophys. Acta 967, 122.
Ponka, P., et al. 1984. Biochim. Biophys. Acta 802, 477.
Ponka, P., et al. 1979. FEBS Lett. 97, 317.