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521234 PDGFR Tyrosine Kinase Inhibitor V - CAS 347155-76-4 - Calbiochem

The PDGFR Tyrosine Kinase Inhibitor V, also referenced under CAS 347155-76-4, controls the biological activity of PDGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(4-((6,7-Dimethoxy-4-quinoyl)oxy)phenyl)-Nʹ-(2-methylbenzoyl)thiourea, Ki11502

Primary Target: PDGFR
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
347155-76-4C₂₆H₂₃N₃O₄S • 3H₂O

Products

Catalogue NumberPackaging Qty/Pack
521234-1MGCN Plastic Bag(s) 1 mg
Description
OverviewA cell-permeable quinolinyl-thiourea compound that acts a potent, ATP-competitive, and reversible inhibitor of PDGFR (IC50 = 4 and 7.6 nM in ligand-induced cellular PDGFR phosphorylation and in in vitro kinase activity, respectively). Inhibits c-kit receptor only at much higher concentrations (IC50 = 434 and 234 nM in receptor phosphorylation and kinase activity, respectively). Shown to potently inhibit neointima formation in a rat carotid artery balloon injury model in vivo (30 mg/kg, p.o.).
Catalogue Number521234
Brand Family Calbiochem®
SynonymsN-(4-((6,7-Dimethoxy-4-quinoyl)oxy)phenyl)-Nʹ-(2-methylbenzoyl)thiourea, Ki11502
References
ReferencesGetachew, R., et al. 2009. Eur. J. Pharmacol.<→i> In press.
Nishioka, C., et al. 2008. Blood 111, 5086.
Furuta, T., et al. 2006. J. Med. Chem. 49, 2186.
Product Information
CAS number347155-76-4
ATP CompetitiveY
FormOff-white solid
Hill FormulaC₂₆H₂₃N₃O₄S • 3H₂O
Chemical formulaC₂₆H₂₃N₃O₄S • 3H₂O
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPDGFR
Primary Target IC<sub>50</sub>4 and 7.6 nM in ligand-induced cellular PDGFR phosphorylation and in in vitro kinase activity, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
521234-1MGCN 04055977271386

Documentation

PDGFR Tyrosine Kinase Inhibitor V - CAS 347155-76-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

PDGFR Tyrosine Kinase Inhibitor V - CAS 347155-76-4 - Calbiochem Certificates of Analysis

TitleLot Number
521234

References

Reference overview
Getachew, R., et al. 2009. Eur. J. Pharmacol.<→i> In press.
Nishioka, C., et al. 2008. Blood 111, 5086.
Furuta, T., et al. 2006. J. Med. Chem. 49, 2186.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-November-2009 RFH
SynonymsN-(4-((6,7-Dimethoxy-4-quinoyl)oxy)phenyl)-Nʹ-(2-methylbenzoyl)thiourea, Ki11502
DescriptionA cell-permeable quinolinyl-thiourea compound that acts a potent, ATP-competitive, and reversible inhibitor of PDGFR (IC50 = 4 and 7.6 nM in ligand-induced cellular PDGFR phosphorylation and in in vitro kinase activity, respectively). Inhibits c-kit receptor only at much higher concentrations (IC50 = 434 and 234 nM in receptor phosphorylation and kinase activity, respectively). Shown to potently inhibit neointima formation in a rat carotid artery balloon injury model in vivo (30 mg/kg, p.o.).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number347155-76-4
Chemical formulaC₂₆H₂₃N₃O₄S • 3H₂O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (25 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Toxic
ReferencesGetachew, R., et al. 2009. Eur. J. Pharmacol.<→i> In press.
Nishioka, C., et al. 2008. Blood 111, 5086.
Furuta, T., et al. 2006. J. Med. Chem. 49, 2186.