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493800 PARP Inhibitor VI, NU1025 - CAS 90417-38-2 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
90417-38-2C₉H₈N₂O₂

Products

Catalogue NumberPackaging Qty/Pack
493800-5MGCN Plastic ampoule 5 mg
Description
OverviewA potent inhibitor poly(ADP-ribose) polymerase (PARP; IC50 = 0.40 µM). Has been shown to potentiate the cytotoxicity of the DNA-methylating agent MTIC [5-(3-N-methyltriazen-1-yl)-imidazole-4-carboxamide] and ionizing irradiation in murine L210 leukemia cells.
Catalogue Number493800
Brand Family Calbiochem®
Synonyms8-Hydroxy-2-methylquinazoline-4-one
References
ReferencesDelaney, C.A., et al. 2000. Clin. Cancer Res. 6, 2860.
Boulton, S., et al. 1999. Carcinogenesis 20, 199.
Bowman, K.J., et al. 1998. Br. J. Cancer 78, 1269.
Griffin, R.J., et al. 1998. J. Med. Chem. 41, 5247.
Griffin, R.J., et al. 1996. Pharm. Sci. 2, 43.
Boulton, S., et al. 1995. Br. J. Cancer 72, 849.
Griffin, R.J., et al. 1995. Anticancer Drug Res. 10, 507.
Product Information
CAS number90417-38-2
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₉H₈N₂O₂
Chemical formulaC₉H₈N₂O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetPARP
Primary Target IC<sub>50</sub>0.4 µM against poly(ADP-ribose) polymerase (PARP)
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
493800-5MGCN 04055977272826