480065 Sigma-AldrichNecrostatin-1 - CAS 4311-88-0 - Calbiochem
Necrostatin-1, CAS 4311-88-0, is a cell-permeable, potent, and selective blocker of necroptosis (EC₅₀ = 494 nM in FADD-deficient Jurkat cells treated with TNF-α).
More>> Necrostatin-1, CAS 4311-88-0, is a cell-permeable, potent, and selective blocker of necroptosis (EC₅₀ = 494 nM in FADD-deficient Jurkat cells treated with TNF-α). Less<<Necrostatin-1 - CAS 4311-88-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Necrosome Inhibitor I, 5-(Indol-3-ylmethyl)-(2-thio-3-methyl)hydantoin, Nec-1, Necrosis Inhibitor II, Methyl-thiohydantoin-tryptophan, MTH-Trp, Receptor-Interacting Protein 1 Inhibitor I, RIPK 1 Inhibitor I, Nec1, RIP1 Inhibitor I
Recommended Products
Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 4311-88-0 | C₁₃H₁₃N₃OS |
Products
| Catalogue Number | Packaging | Qty/Pack | |
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| 480065-5MGCN | Plastic ampoule | 5 mg |
| Description | |
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| Overview | A cell-permeable, potent, and selective blocker of necroptosis (EC50 = 494 nM in FADD-deficient Jurkat cells treated with TNF-α), a nonapoptotic necrotic cell death pathway mediated by death-domain receptors (DRs) that offers neuroprotection in a murine model of ischemic brain injury. Exhibits no effect on DR-induced apoptosis. Also acts as a selective and ATP-competitive inhibitor of RIP1 kinase with negligible effect of RIP2 kinase activity. Nec-1 target appears to be a critical common necroptotic step upstream of execution events and downstream of DRs. Inactive control, Nec-1i, is also available (Cat. No. 480066). Also available as a 25 mM solution in DMSO (Cat. No. 505224). |
| Catalogue Number | 480065 |
| Brand Family | Calbiochem® |
| Synonyms | Necrosome Inhibitor I, 5-(Indol-3-ylmethyl)-(2-thio-3-methyl)hydantoin, Nec-1, Necrosis Inhibitor II, Methyl-thiohydantoin-tryptophan, MTH-Trp, Receptor-Interacting Protein 1 Inhibitor I, RIPK 1 Inhibitor I, Nec1, RIP1 Inhibitor I |
| Product Information | |
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| CAS number | 4311-88-0 |
| ATP Competitive | Y |
| Form | Yellow crystalline solid |
| Hill Formula | C₁₃H₁₃N₃OS |
| Chemical formula | C₁₃H₁₃N₃OS |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | Blocker of necroptosis |
| Primary Target IC<sub>50</sub> | EC50 = 494 nM in blocking necrosis in FADD-deficient Jurkat cells treated with TNF-α |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 480065-5MGCN | 04055977201871 |
Documentation
Necrostatin-1 - CAS 4311-88-0 - Calbiochem SDS
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Necrostatin-1 - CAS 4311-88-0 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 480065 |
References
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| Degterev, A., et al. 2013. Nat. Chem. Biol. 9, 192. Degterev, A., et al. 2012. Cell Death Differ. 20, 366. Christofferson, D.E., et al. 2012. Cell Death Dis. 3, e320. Takahashi, N., et al. 2012. Cell Death Dis. 3, e437. Degterev, A., et al. 2008. Nat. Chem. Biol. 4, 313. Degterev, A., et al. 2005. Nat. Chem. Biol. 1, 112. Muller, A.J., et al. 2005. Nat. Med. 11, 312. Teng, X., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5039. |