444143 Sigma-AldrichMDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem
The MDM2 Antagonist, Nutlin-3, Racemic, also referenced under CAS 548472-68-0, controls the biological activity of MDM2. This small molecule/inhibitor is primarily used for Cancer applications.
More>> The MDM2 Antagonist, Nutlin-3, Racemic, also referenced under CAS 548472-68-0, controls the biological activity of MDM2. This small molecule/inhibitor is primarily used for Cancer applications. Less<<Synonyms: MDM2 Inhibitor IV
Recommended Products
Overview
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Key Spec Table
CAS # | Empirical Formula |
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548472-68-0 | C₃₀H₃₀Cl₂N₄O₄ |
Products
Catalogue Number | Packaging | Qty/Pack | |
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444143-1MGCN | Plastic ampoule | 1 mg |
Description | |
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Overview | A cell-permeable cis-imidazoline compound that acts as a potent and selective MDM2 antagonist (IC50 = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b) and displays antitumor properties. Activates p53 pathway by binding MDM2 in the p53-binding pocket and inhibits MDM2-p53 interaction. Shown to suppress tumor growth by induction of apoptosis in several cancer cells with wild-type p53 and in xenografted tumor mice. A 10 mM (1 mg/172 µl) solution of MDM2 Antagonist, Nutlin-3, Racemic (Cat. No. 444151) in DMSO is also available. |
Catalogue Number | 444143 |
Brand Family | Calbiochem® |
Synonyms | MDM2 Inhibitor IV |
References | |
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References | Thompson, T., et al. 2004. J. Biol. Chem. 279, 53015. Vassilev, L.T., et al. 2004. Science 303, 844. |
Product Information | |
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CAS number | 548472-68-0 |
ATP Competitive | N |
Form | Solid |
Hill Formula | C₃₀H₃₀Cl₂N₄O₄ |
Chemical formula | C₃₀H₃₀Cl₂N₄O₄ |
Reversible | N |
Structure formula Image | |
Quality Level | MQ100 |
Applications |
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Biological Information | |
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Primary Target | MDM2 |
Primary Target IC<sub>50</sub> | 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b |
Purity | ≥98% by TLC and HPLC |
Physicochemical Information | |
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Cell permeable | Y |
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Materials Information |
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Safety Information |
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Product Usage Statements |
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Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
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Supplemental Information |
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Specifications |
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Global Trade Item Number | |
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Catalogue Number | GTIN |
444143-1MGCN | 07790788050337 |
Documentation
MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem SDS
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MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem Certificates of Analysis
Title | Lot Number |
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444143 |
References
Reference overview |
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Thompson, T., et al. 2004. J. Biol. Chem. 279, 53015. Vassilev, L.T., et al. 2004. Science 303, 844. |
Brochure
Title |
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Interactive Pathway Calendar |