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440025 Luteolin - CAS 491-70-3 - Calbiochem

An antioxidant flavonoid and a free radical scavenger.

Luteolin - CAS 491-70-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3ʹ,4ʹ,5,7-Tetrahydroxyflavone

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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
491-70-3C₁₅H₁₀O₆

Products

Catalogue NumberPackaging Qty/Pack
440025-5MGCN Glass bottle 5 mg
Description
OverviewAn antioxidant flavonoid and a free radical scavenger. Inhibits rat liver cytosolic glutathione S-transferase activity. Also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T½CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G2/M phase of the cell cycle. Also shown to inhibit TPL2 kinase.
Catalogue Number440025
Brand Family Calbiochem®
Synonyms3ʹ,4ʹ,5,7-Tetrahydroxyflavone
References
ReferencesKim, J.E., et al. 2011. J. Pharmacol. Exp. Ther. in press.
Korkina, L.G., and Afanasev, I.B. 1997. Adv. Pharmacol. 38, 151.
Plaumann, B., et al. 1996. Oncogene 13, 1605.
Ramanathan, R., et al. 1994. Free Radic. Biol. Med. 16, 43.
Shimoi, L., et al. 1994. Carcinogenesis 15, 2669.
Product Information
CAS number491-70-3
ATP CompetitiveN
FormYellow solid
Hill FormulaC₁₅H₁₀O₆
Chemical formulaC₁₅H₁₀O₆
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetrat liver cytosolic glutathione S-transferase activity
Purity≥90% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSLK9275210
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 weeks at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
440025-5MGCN 04055977187090

Documentation

Luteolin - CAS 491-70-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Luteolin - CAS 491-70-3 - Calbiochem Certificates of Analysis

TitleLot Number
440025

References

Reference overview
Kim, J.E., et al. 2011. J. Pharmacol. Exp. Ther. in press.
Korkina, L.G., and Afanasev, I.B. 1997. Adv. Pharmacol. 38, 151.
Plaumann, B., et al. 1996. Oncogene 13, 1605.
Ramanathan, R., et al. 1994. Free Radic. Biol. Med. 16, 43.
Shimoi, L., et al. 1994. Carcinogenesis 15, 2669.

Brochure

Title
Pathways and Biomarkers of Oxidative Stress
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-July-2011 JSW
Synonyms3ʹ,4ʹ,5,7-Tetrahydroxyflavone
DescriptionAn antioxidant flavonoid and a free radical scavenger. Inhibits rat liver cytosolic glutathione S-transferase activity. Also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T1/2CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G2/M phase of the cell cycle. Also shown to inhibit TPL2 kinase.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number491-70-3
RTECSLK9275210
Chemical formulaC₁₅H₁₀O₆
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityAqueous alkaline solutions (1.4 mg/ml), DMSO (7 mg/ml), or Ethanol
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 weeks at -20°C.
Toxicity Standard Handling
Merck USA index14, 5614
ReferencesKim, J.E., et al. 2011. J. Pharmacol. Exp. Ther. in press.
Korkina, L.G., and Afanasev, I.B. 1997. Adv. Pharmacol. 38, 151.
Plaumann, B., et al. 1996. Oncogene 13, 1605.
Ramanathan, R., et al. 1994. Free Radic. Biol. Med. 16, 43.
Shimoi, L., et al. 1994. Carcinogenesis 15, 2669.