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9016 Lis/Pro Insulin

Iodinated Human Lis/Pro insulin -HPLC purified & prepared fresh monthly.

Lis/Pro Insulin MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
UniProt Number: P01308 Entrez Gene Number: NM_000207.2
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9016
250 tubes  
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Overview

Replacement Information
Description
Catalogue Number9016
DescriptionLis/Pro Insulin
Background InformationThese iodinated hormonos are HPLC purified and prepared fresh monthly.
References
Product Information
Quality LevelMQ100
Applications
ApplicationIodinated Human Lis/Pro insulin -HPLC purified & prepared fresh monthly.
Application Notesappropriate label hydrating buffer if kit replacement or assay buffer of choice
Biological Information
Entrez Gene Number
Entrez Gene SummaryAfter removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake. A variety of mutant alleles with changes in the coding region have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region.
Gene Symbol
  • INS
  • proinsulin
  • insulin
Radioactive Isotype125Iodine
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P01308 # Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
SIZE: 110 amino acids; 11981 Da
SUBUNIT: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
SUBCELLULAR LOCATION: Secreted.
DISEASE:SwissProt: P01308 # Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730].
SIMILARITY: SwissProt: P01308 ## Belongs to the insulin family.
Physicochemical Information
Radioactivity<3 μCi
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions2–8 °C
Packaging Information
Material Size250 tubes
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
9016 04053252326745