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420139 JAK2 Inhibitor IV - CAS 1110502-30-1 - Calbiochem

The JAK2 Inhibitor IV, also referenced under CAS 1110502-30-1, controls the biological activity of JAK2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-Amino-5-(N-tert-butylsulfonamido-4-phenyl)-indazole

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420139
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1110502-30-1C₁₇H₂₀N₄O₂S

Products

Catalogue NumberPackaging Qty/Pack
420139-5MGCN Plastic ampoule 5 mg
Description
OverviewAn aminoindazole compound that potently inhibits the activity of both the wild-type JAK2 and the constitutively active V617F mutant (IC50 = 78 and 206 nM, respectively) frequently found in patients with clonal polycythemia vera, essential thrombocytosis, and chronic idiopathic myelofibrosis, while exhibiting much reduced activity against JAK3 (IC50 = 2.93 µM).
Catalogue Number420139
Brand Family Calbiochem®
Synonyms3-Amino-5-(N-tert-butylsulfonamido-4-phenyl)-indazole
References
ReferencesAntonysamy, S., et al. 2008. Bioorg. Med. Chem. Lett. 19, 279.
Product Information
CAS number1110502-30-1
FormPale yellow solid
Hill FormulaC₁₇H₂₀N₄O₂S
Chemical formulaC₁₇H₂₀N₄O₂S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
420139-5MGCN 04055977187687

Documentation

JAK2 Inhibitor IV - CAS 1110502-30-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

JAK2 Inhibitor IV - CAS 1110502-30-1 - Calbiochem Certificates of Analysis

TitleLot Number
420139

References

Reference overview
Antonysamy, S., et al. 2008. Bioorg. Med. Chem. Lett. 19, 279.

Brochure

Title
Pathways and Biomarkers of JAK/STAT Signaling

Technical Info

Title
JAK/STAT Signaling Research Focus
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
Synonyms3-Amino-5-(N-tert-butylsulfonamido-4-phenyl)-indazole
DescriptionAn aminoindazole compound that potently inhibits the activity of both the wild-type JAK2 and the constitutively active V617F mutant (IC50 = 78 and 206 nM, respectively) frequently found in patients with clonal polycythemia vera, essential thrombocytosis, and chronic idiopathic myelofibrosis, while exhibiting much reduced activity against JAK3 (IC50 = 2.93 µM).
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1110502-30-1
Chemical formulaC₁₇H₂₀N₄O₂S
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (5 mg/ml) or Ethanol (3 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesAntonysamy, S., et al. 2008. Bioorg. Med. Chem. Lett. 19, 279.