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420132 JAK2 Inhibitor II - CAS 1837-91-8 - Calbiochem

The JAK2 Inhibitor II, also referenced under CAS 1837-91-8, controls the biological activity of JAK2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1,2,3,4,5,6-Hexabromocyclohexane

Primary Target: JAK2 autophosphorylation
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1837-91-8C₆H₆Br₆

Products

Catalogue NumberPackaging Qty/Pack
420132-25MGCN Plastic ampoule 25 mg
Description
OverviewA cell-permeable hexabromocyclohexane compound that interacts with a solvent-accessible pocket near the activation loop of JAK2 and acts as a specific, reversible, and direct inhibitor of JAK2 autophosphorylation (maximal inhibition at 50 µM in BSC-40 cells overexpressing JAK2). Reduces growth hormone-mediated JAK2 activation in γ2A cells that stably express growth hormone receptor and JAK2. Does not block EGFR autophosphorylation in murine fibroblasts.
Catalogue Number420132
Brand Family Calbiochem®
Synonyms1,2,3,4,5,6-Hexabromocyclohexane
References
ReferencesSandberg, E.M., et al. 2005. J. Med. Chem. 48, 2526.
Product Information
CAS number1837-91-8
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₆H₆Br₆
Chemical formulaC₆H₆Br₆
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetJAK2 autophosphorylation
Purity≥ 97% by GC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
420132-25MGCN 04055977188103

Documentation

JAK2 Inhibitor II - CAS 1837-91-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

JAK2 Inhibitor II - CAS 1837-91-8 - Calbiochem Certificates of Analysis

TitleLot Number
420132

References

Reference overview
Sandberg, E.M., et al. 2005. J. Med. Chem. 48, 2526.

Technical Info

Title
JAK/STAT Signaling Research Focus
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision02-December-2010 RFH
Synonyms1,2,3,4,5,6-Hexabromocyclohexane
DescriptionA cell-permeable, specific, reversible, and direct inhibitor of JAK2 autophosphorylation (maximal inhibition at 50 µM in BSC-40 cells overexpressing JAK2 that interacts with a solvent-accessible pocket near the activation loop of JAK2. Reduces growth hormone-mediated JAK2 activation in γ2A cells that stably express growth hormone receptor and JAK2. Does not block EGFR autophosphorylation in murine fibroblasts.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1837-91-8
Chemical formulaC₆H₆Br₆
Structure formulaStructure formula
Purity≥ 97% by GC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSandberg, E.M., et al. 2005. J. Med. Chem. 48, 2526.