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405268 Indomethacin - CAS 53-86-1 - Calbiochem

A non-steroidal anti-inflammatory, cell permeable, antipyretic agent.

Indomethacin - CAS 53-86-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid

Primary Target: COX-1
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405268
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
53-86-1C₁₉H₁₆ClNO₄

Products

Catalogue NumberPackaging Qty/Pack
405268-10GMCN Alu drum 10 gm
Description
OverviewA non-steroidal anti-inflammatory, cell permeable, antipyretic agent. Non-selective COX inhibitor (IC50 = 740 nM for COX-1; IC50 = 970 nM for COX-2). Inhibits phospholipase A2 (IC50 = 145 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation and suppresses production of Aβ-peptide and secreted form of APP by inhibition of APP mRNA levels in NG108-15 cells.
Catalogue Number405268
Brand Family Calbiochem®
Synonyms1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid
References
ReferencesKodoyama, K., et al. 2001. Biochem. Biophys. Res. Commun. 281, 483.
Weggen, S., et al. 2001. Nature 414, 212.
Kalgutkar, A.S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 925.
Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
Futaki, N., et al. 1994. Prostaglandins 47, 55.
Futaki, N., et al. 1994. Prostaglandins 47, 55.
Stevenson, K.M., and Lumbers, E.R. 1992. J. Dev. Physiol. 17, 257.
Oliw, E. 1980. Prostaglandins 19, 271.
Product Information
CAS number53-86-1
ATP CompetitiveN
FormWhite to off-white powder
Hill FormulaC₁₉H₁₆ClNO₄
Chemical formulaC₁₉H₁₆ClNO₄
HS Code2933 99 99
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCOX-1
Primary Target IC<sub>50</sub>740 nM
Purity≥98% by assay
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSNL3500000
Safety Information
R PhraseR: 28-42/43-63

Very toxic if swallowed.
May cause sensitization by inhalation and skin contact.
Possible risk of harm to the unborn child.
S PhraseS: 36/37/39-45

Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Highly Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
405268-10GMCN 04055977188493

Documentation

Indomethacin - CAS 53-86-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Indomethacin - CAS 53-86-1 - Calbiochem Certificates of Analysis

TitleLot Number
405268

References

Reference overview
Kodoyama, K., et al. 2001. Biochem. Biophys. Res. Commun. 281, 483.
Weggen, S., et al. 2001. Nature 414, 212.
Kalgutkar, A.S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 925.
Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
Futaki, N., et al. 1994. Prostaglandins 47, 55.
Futaki, N., et al. 1994. Prostaglandins 47, 55.
Stevenson, K.M., and Lumbers, E.R. 1992. J. Dev. Physiol. 17, 257.
Oliw, E. 1980. Prostaglandins 19, 271.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-May-2008 RFH
Synonyms1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid
DescriptionA cell-permeable, non-steroidal anti-inflammatory, anti-pyretic agent. Non-selective cyclooxygenase (COX) inhibitor (IC50 = 740 nM for COX-1; IC50 = 970 nM for COX-2). Inhibits phospholipase A2 (IC50 = 145 µM). Reported to reduce Aβ42 levels independently of COX activity.
FormWhite to off-white powder
CAS number53-86-1
RTECSNL3500000
Chemical formulaC₁₉H₁₆ClNO₄
Structure formulaStructure formula
Purity≥98% by assay
SolubilityEthanol (20 mg/ml)
Storage +15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Highly Toxic & Carcinogenic / Teratogenic
Merck USA index14, 4968
ReferencesKodoyama, K., et al. 2001. Biochem. Biophys. Res. Commun. 281, 483.
Weggen, S., et al. 2001. Nature 414, 212.
Kalgutkar, A.S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 925.
Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
Futaki, N., et al. 1994. Prostaglandins 47, 55.
Futaki, N., et al. 1994. Prostaglandins 47, 55.
Stevenson, K.M., and Lumbers, E.R. 1992. J. Dev. Physiol. 17, 257.
Oliw, E. 1980. Prostaglandins 19, 271.