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402088 Indirubin-3ʹ-monoxime-5-sulphonic Acid - CAS 331467-05-1 - Calbiochem

A potent, reversible, and selective inhibitor of Cdk1 (IC₅₀ = 5 nM) and Cdk5 (IC₅₀ = 7 nM) and glycogen synthase kinase-3β (GSK-3β; IC₅₀ = 80 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: CDK1
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402088
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
331467-05-1C₁₆H₁₁N₃O₅S

Products

Catalogue NumberPackaging Qty/Pack
402088-1MGCN Plastic ampoule 1 mg
Description
OverviewA potent, reversible, and selective inhibitor of Cdk1 (IC50 = 5 nM) and Cdk5 (IC50 = 7 nM) and glycogen synthase kinase-3β (GSK-3β; IC50 = 80 nM). The inhibition is competitive with respect to ATP.
Catalogue Number402088
Brand Family Calbiochem®
References
ReferencesLeclerc, S., et al. 2001. J. Biol. Chem. 276, 251.
Product Information
CAS number331467-05-1
ATP CompetitiveY
FormDark red solid
Hill FormulaC₁₆H₁₁N₃O₅S
Chemical formulaC₁₆H₁₁N₃O₅S
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCDK1
Primary Target IC<sub>50</sub>5 nM, 7 nM, 80 nM, against Cdk1, Cdk5, and glycogen synthase kinase-3β (GSK-3β), respectively
Purity≥97% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 4 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
402088-1MGCN 04055977211801

Documentation

Indirubin-3ʹ-monoxime-5-sulphonic Acid - CAS 331467-05-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Indirubin-3ʹ-monoxime-5-sulphonic Acid - CAS 331467-05-1 - Calbiochem Certificates of Analysis

TitleLot Number
402088

References

Reference overview
Leclerc, S., et al. 2001. J. Biol. Chem. 276, 251.

Brochure

Title
Alzheimer's Disease Brochure & Technical Guide
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
DescriptionA highly potent, reversible, and selective inhibitor of cyclin-dependent kinases 1 and 5 (IC50 = 5 nM for CDK1; IC50 = 7 nM for CDK5). Reported to act by competing with ATP for binding to the catalytic site of the kinase. Also acts as a potent inhibitor of glycogen synthase kinase-3β (GSK-3β; IC50 = 80 nM).
FormDark red solid
Intert gas (Yes/No) Packaged under inert gas
CAS number331467-05-1
Chemical formulaC₁₆H₁₁N₃O₅S
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 4 months at -20°C.
Toxicity Standard Handling
ReferencesLeclerc, S., et al. 2001. J. Biol. Chem. 276, 251.