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553508 InSolution™ Rac1 Inhibitor - Calbiochem

The InSolution™ Rac1Inhibitor, also referenced under CAS 1177865-17-6, controls the biological activity of Rac1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

InSolution™ Rac1 Inhibitor - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Rac1
553508
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₄H₃₅N₇ • 3HCl

Products

Catalogue NumberPackaging Qty/Pack
553508-5MGCN Plastic ampoule 5 mg
Description
Catalogue Number553508
Brand Family Calbiochem®
References
ReferencesDesire, L., et al. 2005. J. Biol. Chem. 280, 37516.
Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618.
Cancelas, J.A., et. at. 2005. Natr. Med. 11, 886.
Product Information
ATP CompetitiveN
FormLiquid
FormulationA 50 mM (5 mg/185 µl) solution of Rac1 Inhibitor (Cat. No. 553502) in H₂O.
Hill FormulaC₂₄H₃₅N₇ • 3HCl
Chemical formulaC₂₄H₃₅N₇ • 3HCl
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetRac1
Primary Target IC<sub>50</sub>~50 µM interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1
Purity≥93% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
553508-5MGCN 04055977193671

Documentation

InSolution™ Rac1 Inhibitor - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ Rac1 Inhibitor - Calbiochem Certificates of Analysis

TitleLot Number
553508

References

Reference overview
Desire, L., et al. 2005. J. Biol. Chem. 280, 37516.
Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618.
Cancelas, J.A., et. at. 2005. Natr. Med. 11, 886.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-December-2010 JSW
DescriptionA cell-permeable pyrimidine compound that specifically inhibits Rac1 GDP/GTP exchange activity by interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1 (IC50 ~ 50 µM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50 to 100 µM). Also shown to effectively inhibit Rac1 and Rac2 activation in Lin- c-kit+ bone marrow cells stimulated with SDF-1α (effective intraperitoneal dose of 1mg/kg). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP or PAK1.
FormLiquid
FormulationA 50 mM (5 mg/185 µl) solution of Rac1 Inhibitor (Cat. No. 553502) in H₂O.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₄H₃₅N₇ • 3HCl
Structure formulaStructure formula
Purity≥93% by HPLC
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Standard Handling
ReferencesDesire, L., et al. 2005. J. Biol. Chem. 280, 37516.
Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618.
Cancelas, J.A., et. at. 2005. Natr. Med. 11, 886.