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481407 InSolution™ NF-κB Activation Inhibitor - Calbiochem

The InSolution™ NF-κB Activation Inhibitor controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: NF-κB transcriptional activation
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481407
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₂H₂₀N₄O

Products

Catalogue NumberPackaging Qty/Pack
481407-1MGCN Plastic Bag(s) 1 mg
Description
Catalogue Number481407
Brand Family Calbiochem®
References
ReferencesTobe, M., et al. 2003. Bioorg. Med. Chem. 11, 383.
Product Information
ATP CompetitiveN
FormLiquid
FormulationA 10 mM (1 mg/281 µl) solution of NF-κB Activation Inhibitor (Cat. No. 481406) in DMSO.
Hill FormulaC₂₂H₂₀N₄O
Chemical formulaC₂₂H₂₀N₄O
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetNF-κB transcriptional activation
Primary Target IC<sub>50</sub>11 nM against NF-κB transcriptional activation in Jurkat cells; 7 nM against LPS-induced TNF-α production in murine splenocytes
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
481407-1MGCN 04055977201512

Documentation

InSolution™ NF-κB Activation Inhibitor - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ NF-κB Activation Inhibitor - Calbiochem Certificates of Analysis

TitleLot Number
481407

References

Reference overview
Tobe, M., et al. 2003. Bioorg. Med. Chem. 11, 383.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-August-2008 RFH
DescriptionA cell-permeable quinazoline compound that acts as a potent inhibitor of NF-κB transcriptional activation (IC50 = 11 nM in Jurkat cells) and LPS-induced TNF-α production (IC50 = 7 nM in murine splenocytes). Does not exhibit cellular cytotoxicity even at concentrations as high as 10 µM. Reported to exhibit anti-inflammatory effects on carregeenin-induced paw edema in rats.
FormLiquid
FormulationA 10 mM (1 mg/281 µl) solution of NF-κB Activation Inhibitor (Cat. No. 481406) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₂H₂₀N₄O
Structure formulaStructure formula
Purity≥98% by HPLC
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
Toxicity Toxic
ReferencesTobe, M., et al. 2003. Bioorg. Med. Chem. 11, 383.