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420297 InSolution™ K-252a, Nocardiopsis sp. - CAS 97161-97-2 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: CaM kinase II
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420297
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
97161-97-2C₂₇H₂₁N₃O₅

Products

Catalogue NumberPackaging Qty/Pack
420297-100UGCN Plastic ampoule 100 μg
Description
Catalogue Number420297
Brand Family Calbiochem®
References
ReferencesChin, L.S., et al. 1999. Cancer Invest. 17, 391.
Nakanishi, N., et al. 1995. FEBS Lett. 368, 411.
Ross, A.H., et al. 1995. J. Neurochem. 65, 2748.
Mizuno, K., et al. 1993. FEBS Lett. 330, 114.
Pawlowska, Z., et al. 1993. J. Neurochem. 60, 678.
Tapley, P., et al. 1992. Oncogene 7, 371.
Simpson, D.L., et al. 1991. J. Neurosci. Res. 28, 486.
Hashimoto, S. 1988. J. Cell Biol. 107, 1531.
Koizuma, S., et al. 1988. J. Neurosci. 8, 715.
Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.
Product Information
CAS number97161-97-2
ATP CompetitiveY
FormLiquid
FormulationA 1 mM (100 µg/214 µl) solution of K-252a (Cat. No. 420298) in DMSO.
Hill FormulaC₂₇H₂₁N₃O₅
Chemical formulaC₂₇H₂₁N₃O₅
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCaM kinase II
Primary Target K<sub>i</sub>1.8 nM, 20 nM, 18 nM, 25 nM, 20 nM, 3 nM, against CaM kinase II, myosin light chain kinase, protein kinase A, protein kinase C, protein kinase G, NGF receptor gp140trk, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 26

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw aliquot and freeze at (-20°C). Store under an inert atmosphere.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
420297-100UGCN 04055977210903

Documentation

InSolution™ K-252a, Nocardiopsis sp. - CAS 97161-97-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ K-252a, Nocardiopsis sp. - CAS 97161-97-2 - Calbiochem Certificates of Analysis

TitleLot Number
420297

References

Reference overview
Chin, L.S., et al. 1999. Cancer Invest. 17, 391.
Nakanishi, N., et al. 1995. FEBS Lett. 368, 411.
Ross, A.H., et al. 1995. J. Neurochem. 65, 2748.
Mizuno, K., et al. 1993. FEBS Lett. 330, 114.
Pawlowska, Z., et al. 1993. J. Neurochem. 60, 678.
Tapley, P., et al. 1992. Oncogene 7, 371.
Simpson, D.L., et al. 1991. J. Neurosci. Res. 28, 486.
Hashimoto, S. 1988. J. Cell Biol. 107, 1531.
Koizuma, S., et al. 1988. J. Neurosci. 8, 715.
Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.

Citations

Title
  • Huanyu Dou, et al. (2005) Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. Journal of Neuroscience 25, 8375-8385.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision30-July-2008 JSW
    DescriptionA cell-permeable protein kinase inhibitor that inhibits CaM kinase II (Ki = 1.8 nM), myosin light chain kinase (Ki = 17 nM), protein kinase A (Ki = 18 nM), protein kinase C (Ki = 25 nM), and protein kinase G (Ki = 20 nM). Also acts as a potent inhibitor (IC50 = 3 nM) of the tyrosine protein kinase activity of the NGF receptor gp 140trk, the product of the trk protooncogene. Also inhibits the kinase activity of its transforming alleles, the trk oncogenes, and of the related neurotrophin receptors gp 145trkB and gp 145trkC. Induces apoptosis and cell cycle arrest by inhibiting Cdc2 and Cdc25c.
    FormLiquid
    FormulationA 1 mM (100 µg/214 µl) solution of K-252a (Cat. No. 420298) in DMSO.
    Intert gas (Yes/No) Packaged under inert gas
    CAS number97161-97-2
    Chemical formulaC₂₇H₂₁N₃O₅
    Structure formulaStructure formula
    Purity≥95% by HPLC
    Storage Protect from light
    -20°C
    Hygroscopic
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing initial thaw aliquot and freeze at (-20°C). Store under an inert atmosphere.
    Toxicity Irritant
    ReferencesChin, L.S., et al. 1999. Cancer Invest. 17, 391.
    Nakanishi, N., et al. 1995. FEBS Lett. 368, 411.
    Ross, A.H., et al. 1995. J. Neurochem. 65, 2748.
    Mizuno, K., et al. 1993. FEBS Lett. 330, 114.
    Pawlowska, Z., et al. 1993. J. Neurochem. 60, 678.
    Tapley, P., et al. 1992. Oncogene 7, 371.
    Simpson, D.L., et al. 1991. J. Neurosci. Res. 28, 486.
    Hashimoto, S. 1988. J. Cell Biol. 107, 1531.
    Koizuma, S., et al. 1988. J. Neurosci. 8, 715.
    Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.
    Citation
  • Huanyu Dou, et al. (2005) Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. Journal of Neuroscience 25, 8375-8385.
    		•

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    Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase A (PKA; cAMP-Dependent Protein Kinase) Inhibitors
    Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase G (PKG; cGMP-Dependent Protein Kinase) Inhibitors
    Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Calmodulin-Dependent Protein Kinase (CaM Kinase) Inhibitors