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364206 InSolution™ GM 6001 - Calbiochem

InSolution™ GM 6001, CAS 142880-36-2, is a 10 mM (1 mg/257 µl) solution of GM6001 in DMSO. A potent, cell-permeable, broad-spectrum inhibitor of MMPs.

InSolution™ GM 6001 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: MMP-1
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364206
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₀H₂₈N₄O₄

Products

Catalogue NumberPackaging Qty/Pack
364206-1MGCN Plastic ampoule 1 mg
Description
Catalogue Number364206
Brand Family Calbiochem®
References
ReferencesSolorzano, C.C., et al. 1997. Shock 7, 427.
Galardy, R.E., et al. 1994. Ann. NY Acad. Sci. 732, 315.
Galardy, R.E., et al. 1994. Cancer Res. 54, 4715.
Galardy, R.E., et al. 1993. Drugs Future 18, 1109.
Grobelny, D., et al. 1992. Biochemistry 31, 7152.
Product Information
ATP CompetitiveN
FormLiquid
FormulationA 10 mM (1 mg/257 µl) solution of GM6001 (Cat. No. 364205) in DMSO.
Hill FormulaC₂₀H₂₈N₄O₄
Chemical formulaC₂₀H₂₈N₄O₄
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
ApplicationInSolution™ GM 6001, CAS 142880-36-2, is a 10 mM (1 mg/257 µl) solution of GM6001 in DMSO. A potent, cell-permeable, broad-spectrum inhibitor of MMPs.
Biological Information
Primary TargetMMP-1
Primary Target K<sub>i</sub>400 pM for MMP-1; 500 pM for MMP-2; 27 nM for MMP-3; 100 pM for MMP-8; and 200 pM for MMP-9
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
364206-1MGCN 04055977213812

Documentation

InSolution™ GM 6001 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ GM 6001 - Calbiochem Certificates of Analysis

TitleLot Number
364206

References

Reference overview
Solorzano, C.C., et al. 1997. Shock 7, 427.
Galardy, R.E., et al. 1994. Ann. NY Acad. Sci. 732, 315.
Galardy, R.E., et al. 1994. Cancer Res. 54, 4715.
Galardy, R.E., et al. 1993. Drugs Future 18, 1109.
Grobelny, D., et al. 1992. Biochemistry 31, 7152.

Citations

Title
  • K. Fredriksson, et al. (2006) Red blood cells increase secretion of matrix metalloproteinases from human lung fibroblasts in vitro. American Journal of Physiology Lung Cellular and Molecular Physiology 290, L326-L333.
  • Daniel W. Lambert, et al. (2005) Tumor Necrosis Factor- Convertase (ADAM17) Mediates Regulated Ectodomain Shedding of the Severe-acute Respiratory Syndrome-Coronavirus (SARS-CoV) Receptor, Angiotensin-converting Enzyme-2 (ACE2). Journal of Biological Chemistry 280, 30113-30119.
  • Haili Su, et al. (2005) Noninvasive targeted imaging of matrix metalloproteinase activation in a murine model of postinfarction remodeling. Circulation 112, 3157-3167.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision02-July-2008 RFH
    DescriptionA potent broad-spectrum hydroxamic acid inhibitor of matrix metalloproteinases (MMPs). Inhibits MMPs in vitro [Ki = 0.4 nM for skin fibroblast collagenase (MMP-1); Ki = 0.5 nM for gelatinase A (MMP-2); Ki = 27 nM for stromelysin (MMP-3); Ki = 0.1 nM for neutrophil collagenase (MMP-8); and Ki = 0.2 nM for gelatinase B (MMP-9)]. Also prevents the release of TNF-α in vivo and in vitro and abrogates endotoxin-induced lethality in mice.
    FormLiquid
    FormulationA 10 mM (1 mg/257 µl) solution of GM6001 (Cat. No. 364205) in DMSO.
    Intert gas (Yes/No) Packaged under inert gas
    Chemical formulaC₂₀H₂₈N₄O₄
    Purity≥95% by HPLC
    Storage Protect from light
    +2°C to +8°C
    Hygroscopic
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
    Toxicity Irritant
    ReferencesSolorzano, C.C., et al. 1997. Shock 7, 427.
    Galardy, R.E., et al. 1994. Ann. NY Acad. Sci. 732, 315.
    Galardy, R.E., et al. 1994. Cancer Res. 54, 4715.
    Galardy, R.E., et al. 1993. Drugs Future 18, 1109.
    Grobelny, D., et al. 1992. Biochemistry 31, 7152.
    Citation
  • K. Fredriksson, et al. (2006) Red blood cells increase secretion of matrix metalloproteinases from human lung fibroblasts in vitro. American Journal of Physiology Lung Cellular and Molecular Physiology 290, L326-L333.
  • Daniel W. Lambert, et al. (2005) Tumor Necrosis Factor- Convertase (ADAM17) Mediates Regulated Ectodomain Shedding of the Severe-acute Respiratory Syndrome-Coronavirus (SARS-CoV) Receptor, Angiotensin-converting Enzyme-2 (ACE2). Journal of Biological Chemistry 280, 30113-30119.
  • Haili Su, et al. (2005) Noninvasive targeted imaging of matrix metalloproteinase activation in a murine model of postinfarction remodeling. Circulation 112, 3157-3167.
    		•