171261 Sigma-AldrichInSolution™ AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem
InSolution™ AMPK Inhibitor, Compound C, CAS 866405-64-3, is a 10 mM (1 mg/250 µl) solution of AMPK Inhibitor, Compound C (Cat. No. 171260) in DMSO.
More>> InSolution™ AMPK Inhibitor, Compound C, CAS 866405-64-3, is a 10 mM (1 mg/250 µl) solution of AMPK Inhibitor, Compound C (Cat. No. 171260) in DMSO. Less<<Synonyms: Dorsomorphin, AMPK Inhibitor I, BMP Inhibitor I
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Overview
Key Spec Table
CAS # | Empirical Formula |
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866405-64-3 | C₂₄H₂₅N₅O |
Products
Catalogue Number | Packaging | Qty/Pack | |
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171261-1MGCN | Plastic ampoule | 1 mg |
Description | |
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Overview | A cell-permeable pyrrazolopyrimidine compound that inhibits against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC50 = 25.1, 148, and 234.6 nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFβR-I, ZAPK, Syk, PKCθ, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC100 = 2.5 µM) and VEGF signaling-dependent intersomitic vessel formation (EC50 = 5 µM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR (Cat. No. 123040) and/or Metformin (Cat. No. 317240) for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo. |
Catalogue Number | 171261 |
Brand Family | Calbiochem® |
Synonyms | Dorsomorphin, AMPK Inhibitor I, BMP Inhibitor I |
Product Information | |
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CAS number | 866405-64-3 |
ATP Competitive | Y |
Form | Liquid |
Formulation | Supplied as a 10 mM (1 mg/250 µl) solution of AMPK Inhibitor, Compound C (Cat. No. 171260) in DMSO. |
Hill Formula | C₂₄H₂₅N₅O |
Chemical formula | C₂₄H₂₅N₅O |
Hygroscopic | Hygroscopic |
Reversible | Y |
Structure formula Image | |
Quality Level | MQ100 |
Physicochemical Information | |
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Cell permeable | Y |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Catalogue Number | GTIN |
171261-1MGCN | 04055977207170 |